Precision Oncology in Surgery: Patient Selection for Operable Pancreatic Cancer.

Annals of Surgery
Stephan B DreyerGlasgow Precision Oncology Laboratory

Abstract

We aimed to define preoperative clinical and molecular characteristics that would allow better patient selection for operative resection. Although we use molecular selection methods for systemic targeted therapies, these principles are not applied to surgical oncology. Improving patient selection is of vital importance for the operative treatment of pancreatic cancer (pancreatic ductal adenocarcinoma). Although surgery is the only chance of long-term survival, 80% still succumb to the disease and approximately 30% die within 1 year, often sooner than those that have unresected local disease. In 3 independent pancreatic ductal adenocarcinoma cohorts (total participants = 1184) the relationship between aberrant expression of prometastatic proteins S100A2 and S100A4 and survival was assessed. A preoperative nomogram based on clinical variables available before surgery and expression of these proteins was constructed and compared to traditional measures, and a postoperative nomogram. High expression of either S100A2 or S100A4 was independent poor prognostic factors in a training cohort of 518 participants. These results were validated in 2 independent patient cohorts (Glasgow, n = 198; Germany, n = 468). Aberrant biomarker expressi...Continue Reading

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Citations

Aug 13, 2020·European Journal of Nuclear Medicine and Molecular Imaging·F B AchterbergA L Vahrmeijer
Apr 14, 2019·Expert Review of Gastroenterology & Hepatology·Erkut BorazanciAlbert Amini
Sep 9, 2020·International Journal of Cancer. Journal International Du Cancer·Satoshi NishiwadaAjay Goel
Jul 7, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Alma L MoekotteMollie Freedman-Weiss
Nov 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R CasolinoT Golan
Aug 24, 2021·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·Susanne Roth, Thilo Hackert

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Methods Mentioned

BETA
surgical resection
biopsies
pancreatectomy
biopsy

Software Mentioned

SPSS
R

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