Precision oncology in urothelial cancer.

ESMO Open
Elizabeth Liow, Ben Tran

Abstract

Genomics-driven, precision medicine has been adopted in virtually every tumour type and underlies the significant advances in cancer management to date. The paradigm shift from the indiscriminate use of chemotherapeutics, to strategies that harness our mechanistic knowledge of cancer biology has led to profound clinical benefit for patients, and will continue to mould present and future treatment approaches. In the realm of urothelial cancer, the present status of precision medicine includes a rich landscape that encompasses molecularly-matched therapy, predictive biomarkers that could help inform response to chemotherapy and immunotherapy, as well as novel strategies such as antibody drug conjugates that exploit the use of target proteins for enhanced tumour killing. Here, we present an overview on these clinically-impactful discoveries in urothelial cancer, discuss the limitations and challenges in the implementation of precision oncology, and offer our vision for its future.

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Citations

Sep 23, 2021·Der Urologe. Ausg. A·Gerald B SchulzNadine T Gaisa

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Clinical Trials Mentioned

NCT02365597
NCT02401542
NCT01856101
NCT00972686
NCT01551030
NCT02236195
NCT02780687
NCT03219333
NCT03547973
NCT03390504

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