Precision renal medicine: a roadmap towards targeted kidney fibrosis therapies

Fibrogenesis & Tissue Repair
Michael Zeisberg, Elisabeth M Zeisberg

Abstract

Based on extensive pre-clinical achievements over the past decades, it appears to be due time for a successful clinical translation in the renal fibrosis field-but what is the quickest road to get there? In light of the recent launch of the Precision Medicine Initiative and success of molecularly informed drugs in oncology, we here discuss what it may take to bring molecularly targeted anti-fibrotic to clinical use in chronic progressive kidney disease.

References

Dec 1, 1975·Journal of Immunological Methods·S A LeonB Shapiro
Sep 3, 1991·Klinische Wochenschrift·G A MüllerH P Rodemann
Oct 1, 1989·Pathology, Research and Practice·A BohleG A Müller
Nov 13, 1998·The New England Journal of Medicine·G Remuzzi, T Bertani
May 1, 1957·Proceedings of the Society for Experimental Biology and Medicine·H E SKIPPERJ J JOHNSON
Oct 10, 2003·The New England Journal of Medicine·John M Goldman, Junia V Melo
Nov 1, 2008·Cancer Research·Vincent T DeVita, Edward Chu
Mar 20, 2010·Clinical Pharmacology and Therapeutics·F StegmeierM Dorsch
Apr 27, 2010·Nature Medicine·Wibke BechtelMichael Zeisberg
May 14, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Stuart J Schnitt
Aug 7, 2010·Fibrogenesis & Tissue Repair·Yohei Maeshima, Hirofumi Makino
Sep 25, 2010·Journal of the American Society of Nephrology : JASN·Michael Zeisberg, Eric G Neilson
Dec 3, 2010·The New England Journal of Medicine·Taegyun KimMin-Geol Lee
Feb 3, 2011·Fibrogenesis & Tissue Repair·Qingjian WangDavid Yeowell
Apr 8, 2011·Fibrogenesis & Tissue Repair·Pierre Galichon, Alexandre Hertig
Aug 25, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kai-Uwe EckardtStephanie Titze
Apr 6, 2012·PLoS Genetics·Cristian PattaroCaroline S Fox
Sep 5, 2012·Fibrogenesis & Tissue Repair·Dong FanZamaneh Kassiri
Sep 12, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Apostolia-Maria TsimberidouRazelle Kurzrock
Oct 2, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Jayanta GuptaUNKNOWN CRIC Study Investigators
Oct 26, 2012·The Journal of Pathology·Elisabeth M Zeisberg, Michael Zeisberg
Dec 21, 2012·American Journal of Physiology. Cell Physiology·Michael Zeisberg, Raghu Kalluri
Jan 3, 2013·British Journal of Haematology·George A FollowsMike A Scott
Mar 15, 2013·The New England Journal of Medicine·Sarah-Jane DawsonNitzan Rosenfeld
May 30, 2013·American Society of Clinical Oncology Educational Book·Javier MunozRazelle Kurzrock
Sep 21, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Björn Tampe, Michael Zeisberg
Nov 2, 2013·Journal of the American Society of Nephrology : JASN·Katalin Susztak
Nov 28, 2013·Fibrogenesis & Tissue Repair·Christian LiedtkeRalf Weiskirchen
Dec 29, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Adeera LevinUNKNOWN CanPREDDICT Investigators
Feb 12, 2014·Nature Reviews. Nephrology·Desiree Tampe, Michael Zeisberg
Feb 12, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maria R WingUNKNOWN Chronic Renal Insufficiency Cohort (CRIC) Study
Feb 21, 2014·Science Translational Medicine·Chetan BettegowdaLuis A Diaz
Mar 7, 2014·Nature·Erika Check Hayden
Apr 1, 2014·Fibrogenesis & Tissue Repair·Federica GenovesePeter Boor
Aug 1, 2014·Nature·Ed Yong

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Citations

Jan 18, 2016·Biochemical and Biophysical Research Communications·Xiaoying TanMichael Zeisberg
Aug 7, 2017·Journal of Nephrology·Grazia Maria VirzìClaudio Ronco

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Methods Mentioned

BETA
biopsies
imaging techniques
biopsy

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