Precision Targeted Ablation of Fine Neurovascular Structures In Vivo Using Dual-mode Ultrasound Arrays.

Scientific Reports
Rajagopal N AravalliEmad S Ebbini

Abstract

Carotid bodies (CBs) are chemoreceptors that monitor and register changes in the blood, including the levels of oxygen, carbon dioxide, and pH, and regulate breathing. Enhanced activity of CBs was shown to correlate with a significant elevation in the blood pressure of patients with hypertension. CB removal or denervation were previously shown to reduce hypertension. Here we demonstrate the feasibility of a dual-mode ultrasound array (DMUA) system to safely ablate the CB in vivo in a spontaneously hypertensive rat (SHR) model of hypertension. DMUA imaging was used for guiding and monitoring focused ultrasound (FUS) energy delivered to the target region. In particular, 3D imaging was used to identify the carotid bifurcation for targeting the CBs. Intermittent, high frame rate imaging during image-guided FUS (IgFUS) delivery was used for monitoring the lesion formation. DMUA imaging provided feedback for closed-loop control (CLC) of the lesion formation process to avoid overexposure. The procedure was tolerated well in over 100 SHR and normotensive rats that received unilateral and bilateral treatments. The measured mean arterial pressure (MAP) exhibited measurable deviation from baseline 2-4 weeks post IgFUS treatment. The resul...Continue Reading

References

Jun 1, 1984·International Journal of Radiation Oncology, Biology, Physics·S A Sapareto, W C Dewey
Jan 1, 1993·European Urology·G R ter Haar, D Robertson
Feb 5, 2003·Physics in Medicine and Biology·A Vanne, K Hynynen
Jan 1, 1956·A.M.A. Archives of Neurology and Psychiatry·J W BARNARDJ F BRENNAN
Oct 1, 1956·Neurology·W J FRY
Sep 23, 2003·The British Journal of Radiology·J E KennedyD Cranston
Oct 7, 2003·The Journal of Physiology·Henri J L M TimmersJacques W M Lenders
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Mar 6, 2004·American Journal of Hypertension·Paul A SmithDavid A S G Mary
May 14, 2004·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Jérémy BercoffMathias Fink
Apr 6, 2006·The Journal of the Acoustical Society of America·Vera A KhokhlovaLawrence A Crum
Aug 29, 2006·Progress in Biophysics and Molecular Biology·William D O'Brien
Nov 11, 2006·Ultrasonic Imaging·Emad S EbbiniAjay Shrestha
Jun 9, 2007·Expert Review of Anticancer Therapy·Feng WuWei R Chen
Aug 10, 2010·Ultrasound in Medicine & Biology·James McLaughlanGail Ter Haar
Dec 3, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Britta Veitenheimer, John W Osborn
Apr 2, 2013·International Journal of Cardiology·Piotr NiewińskiPiotr Ponikowski
May 28, 2013·IEEE Transactions on Bio-medical Engineering·Andrew J CasperEmad S Ebbini
Sep 5, 2013·Nature Communications·Fiona D McBrydeJulian F R Paton
Nov 26, 2013·Journal of Vascular and Interventional Radiology : JVIR·Islam A ShehataEmad S Ebbini
Dec 20, 2013·Physics in Medicine and Biology·Eli VlaisavljevichZhen Xu
Dec 4, 2014·Trends in Cardiovascular Medicine·Murray Esler
Jan 24, 2015·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Emad S Ebbini, Gail ter Haar
Mar 15, 2015·Circulation Research·Suzanne Oparil, Roland E Schmieder
Dec 17, 2015·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Alyona HaritonovaEmad S Ebbini
Jul 3, 2016·Current Hypertension Reports·Fu L NgMelvin D Lobo
Aug 10, 2016·Autonomic Neuroscience : Basic & Clinical·Fiona D McBrydeJulian F R Paton
Jan 5, 2017·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·L-J LiaoT-W Huang
Jan 27, 2017·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Apr 22, 2017·American Journal of Hypertension·Kana FujiiKenji Sunagawa
Jun 18, 2017·Current Hypertension Reports·Jens Jordan
Sep 6, 2017·AJR. American Journal of Roentgenology·Dominik SwietonMaciej Piskunowicz

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Citations

Jul 28, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·M H A GroenR van Es

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Methods Mentioned

BETA
surgical resection
light microscopy
imaging techniques

Software Mentioned

MATLAB Statistics and Machine Learning Toolbox
DMUA

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