Precision wearable accelerometer contact microphones for longitudinal monitoring of mechano-acoustic cardiopulmonary signals.

NPJ Digital Medicine
Pranav GuptaFarrokh Ayazi

Abstract

Mechano-acoustic signals emanating from the heart and lungs contain valuable information about the cardiopulmonary system. Unobtrusive wearable sensors capable of monitoring these signals longitudinally can detect early pathological signatures and titrate care accordingly. Here, we present a wearable, hermetically-sealed high-precision vibration sensor that combines the characteristics of an accelerometer and a contact microphone to acquire wideband mechano-acoustic physiological signals, and enable simultaneous monitoring of multiple health factors associated with the cardiopulmonary system including heart and respiratory rate, heart sounds, lung sounds, and body motion and position of an individual. The encapsulated accelerometer contact microphone (ACM) utilizes nano-gap transducers to achieve extraordinary sensitivity in a wide bandwidth (DC-12 kHz) with high dynamic range. The sensors were used to obtain health factors of six control subjects with varying body mass index, and their feasibility in detection of weak mechano-acoustic signals such as pathological heart sounds and shallow breathing patterns is evaluated on patients with preexisting conditions.

References

Feb 27, 1982·British Medical Journal·J P McFaddenR S Briggs
Jun 5, 2003·Annals of Internal Medicine·Thomas J WangRamachandran S Vasan
Jan 1, 1954·Circulation·H B SPRAGUE, P A ONGLEY
Oct 2, 2004·International Journal of Cardiology·Nirav J Mehta, Ijaz A Khan
Feb 7, 2007·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·M PourazadR Ward
Jan 24, 2009·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Tiago H Falk, Wai-Yip Chan
May 12, 2010·Nature Reviews. Cardiology·Geoffrey de CoutoPeter P Liu
Jan 1, 2008·Clinical Medicine. Circulatory, Respiratory and Pulmonary Medicine·Sandra ReichertEmmanuel Andrès
Jan 1, 2010·The Open Biomedical Engineering Journal·Eduardo PinheiroPedro Girão
Nov 1, 2011·Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association·Guan-Zheng LiuLei Wang
Aug 4, 2012·Journal of the American College of Cardiology·David S CelermajerKam S Woo
Dec 21, 2012·Pacing and Clinical Electrophysiology : PACE·Krzysztof Z SiejkoMaria-Teresa Olivari
Feb 21, 2014·The New England Journal of Medicine·Abraham BohadanaSteve S Kraman
Jan 9, 2015·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Carson A WickSrini Tridandapani
Apr 17, 2015·Science Translational Medicine·Steven R SteinhublEric J Topol
Aug 1, 2015·Annals of Thoracic Medicine·Malay SarkarMegha Dogra
Dec 25, 2015·Science Translational Medicine·Jonathan A KirkDavid A Kass
Mar 5, 2016·Nature Reviews. Cardiology·Boback Ziaeian, Gregg C Fonarow
May 12, 2017·Nature Reviews. Cardiology·Shannon M DunlayMargaret M Redfield
Aug 9, 2017·Cardiac Failure Review·Gianluigi Savarese, Lars H Lund
Aug 19, 2017·Trends in Cardiovascular Medicine·Joshua M PevnickIlan Kedan
Aug 25, 2017·Nature Reviews. Disease Primers·Michelle W BloomJaved Butler
Jan 19, 2018·Science Translational Medicine·Michele MiragoliDaniele Catalucci
Jul 13, 2018·JAMA : the Journal of the American Medical Association·Steven R SteinhublEric J Topol
Sep 28, 2018·Personalized Medicine·Jessilyn DunnMichael Snyder
Feb 26, 2019·Nature Biotechnology·Jayoung KimJoseph Wang
Jul 16, 2019·NPJ Digital Medicine·Michael ChuMichelle Khine

❮ Previous
Next ❯

Citations

Oct 11, 2020·Nature Reviews. Cardiology·Chayakrit KrittanawongSanjiv M Narayan

❮ Previous
Next ❯

Methods Mentioned

BETA
microsensor
chip
biosensors

Software Mentioned

COMSOL Multiphysics simulation
MATLAB

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation
Feiba ChangDeqiang Zhou
Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
David Barbosa RendónMiguel A Fernández
Clinical Cases in Mineral and Bone Metabolism : the Official Journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases
Raoul SagginiRosa Grazia Bellomo
© 2021 Meta ULC. All rights reserved