Preclinical 89Zr Immuno-PET of High-Grade Serous Ovarian Cancer and Lymph Node Metastasis

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Sai Kiran SharmaJason S Lewis

Abstract

The elevation of cancer antigen 125 (CA125) levels in the serum of asymptomatic patients precedes the radiologic detection of high-grade serous ovarian cancer by at least 2 mo and the final clinical diagnosis by 5 mo. PET imaging of CA125 expression by ovarian cancer cells may enhance the evaluation of the extent of disease and provide a roadmap to surgery as well as detect recurrence and metastases. (89)Zr-labeled mAb-B43.13 was synthesized to target CA125 and evaluated via PET imaging and biodistribution studies in mice bearing OVCAR3 human ovarian adenocarcinoma xenografts. Ex vivo analysis of tumors and lymph nodes was performed via autoradiography, histopathology, and immunohistochemistry. PET imaging using (89)Zr-DFO-mAb-B43.13 (DFO is desferrioxamine) clearly delineated CA125-positive OVCAR3 xenografts as early as 24 h after the administration of the radioimmunoconjugate. Biodistribution studies revealed accretion of (89)Zr-DFO-mAb-B43.13 in the OVCAR3 tumors, ultimately reaching 22.3 ± 6.3 percentage injected dose per gram (%ID/g) at 72 h after injection. Most interestingly, activity concentrations greater than 50 %ID/g were observed in the ipsilateral lymph nodes of the xenograft-bearing mice. Histopathologic analysis ...Continue Reading

References

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Citations

Mar 9, 2017·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Vladimir Ponomarev
May 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kimberly FungBrian M Zeglis
Feb 11, 2020·Frontiers in Oncology·Sridhar Nimmagadda, Marie-France Penet
Dec 30, 2020·Cancers·Ruben D HouvastCornelis F M Sier
Apr 30, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sai Kiran SharmaBrian M Zeglis
Jun 1, 2021·ACS Medicinal Chemistry Letters·Jatinder KaurFrank Wuest
Mar 24, 2020·Chemical Reviews·Weijun WeiWeibo Cai

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