Preclinical and clinical development of pegylated interferon-lambda 1 in chronic hepatitis C

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Eleanor L Ramos

Abstract

Current treatment of chronic hepatitis C consists of pegylated interferon-alpha (PEG-IFN-alpha) in combination with ribavirin. This regimen is associated with adverse effects that can limit its use. PEG-IFN-lambda 1 (pegIFNlambda) is a novel IFN that shares many of the biological effects of IFN-alpha but may have fewer side effects due to its more selective receptor distribution. Preclinical data show that pegIFNlambda has antiviral activity against hepatitis C virus (HCV) but does not inhibit myeloid colony formation. A phase 1 study in healthy volunteers demonstrated that pegIFNlambda is well tolerated. Elevated liver enzymes resulted in a dose-limiting toxicity after a single dose of 7.5 microg/kg, the highest dose tested. A phase 1b study in genotype 1 HCV patients who either relapsed after IFN-alpha therapy or naive to therapy was initiated. Interim data from the treatment relapse subset showed viral load reductions of 2.3 to 4.0 logs when pegIFNlambda was administered weekly as a single agent with or without ribavirin for up to 4 weeks. Drug-related side effects included elevation of liver enzymes. Decreases in hemoglobin were observed only in patients receiving ribavirin. Constitutional symptoms appeared lower than histo...Continue Reading

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Citations

Aug 18, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Raymond P Donnelly, Sergei V Kotenko
Jan 28, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Kelly A Byrnes-BlakeJeremy A Freeman
Dec 24, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Heinz ZollerDietmar Fuchs
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Nov 1, 2018·Molecular & Cellular Proteomics : MCP·Jiradej MakjaroenTrairak Pisitkun
Jul 3, 2021·Microorganisms·Chiara MedagliaCaroline Tapparel

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