Preclinical assessment for selectively disrupting a traumatic memory via postretrieval inhibition of glucocorticoid receptors.

Biological Psychiatry
Stephen M TaubenfeldCristina M Alberini

Abstract

Traumatic experiences may lead to debilitating psychiatric disorders including acute stress disorder and posttraumatic stress disorder. Current treatments for these conditions are largely ineffective, and novel therapies are needed. A cardinal symptom of these pathologies is the reexperiencing of the trauma through intrusive memories and nightmares. Studies in animal models indicate that memories can be weakened by interfering with the postretrieval restabilization process known as memory reconsolidation. We previously reported that, in rats, intraamygdala injection of the glucocorticoid receptor antagonist RU38486 disrupts the reconsolidation of a traumatic memory. Here we tested parameters important for designing novel clinical protocols targeting the reconsolidation of a traumatic memory with RU38486. Using rat inhibitory avoidance, we tested the efficacy of postretrieval systemic administration of RU38486 on subsequent memory retention and evaluated several key preclinical parameters. Systemic administration of RU38486 before or after retrieval persistently weakens inhibitory avoidance memory retention in a dose-dependent manner, and memory does not reemerge following a footshock reminder. The efficacy of treatment is a fun...Continue Reading

References

Jan 1, 1987·Journal of Clinical Psychology·J A Fairbank, R A Nicholson
Dec 1, 1995·Archives of General Psychiatry·R C KesslerC B Nelson
Aug 1, 1994·The European Journal of Neuroscience·C Sandi, S P Rose
Jul 1, 1997·The British Journal of Psychiatry : the Journal of Mental Science·J I BissonC Bannister
Apr 19, 2000·JAMA : the Journal of the American Medical Association·K BradyG M Farfel
Jun 9, 2000·Annual Review of Neuroscience·J E LeDoux
Feb 24, 2001·Psychological Review·M E BoutonD H Barlow
Jul 27, 2001·Journal of Traumatic Stress·K M Campfield, A M Hills
Oct 11, 2001·Journal of Clinical Psychopharmacology·J K BelanoffA F Schatzberg
May 16, 2002·Neurology·Nunzio PomaraSteven Ferris
Sep 21, 2002·Biological Psychiatry·Joseph K BelanoffAlan F Schatzberg
Nov 1, 2002·Neuron·Maria H Milekic, Cristina M Alberini
Mar 6, 2004·Annals of the New York Academy of Sciences·Barbara Olasov Rothbaum, Michael Davis
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·K Matthew Lattal, Ted Abel
May 6, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Allan H YoungI Nicol Ferrier
May 21, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Akinobu SuzukiSatoshi Kida
Oct 22, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sevil Duvarci, Karim Nader
Nov 3, 2004·Neuroscience Letters·Douglas Barrett, F Gonzalez-Lima
Nov 24, 2004·Behavior Modification·Matt J Gray, Brett T Litz
May 14, 2005·The Journal of Clinical Psychiatry·George M SimpsonWaleed Fawzy
Jun 25, 2005·Current Alzheimer Research·Charles DeBattista, Joseph Belanoff
Aug 13, 2005·Neuroscience and Biobehavioral Reviews·Vinuta RauMichael S Fanselow
Sep 15, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Benjamin H FloresAlan F Schatzberg
Oct 6, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yi-Ling YangKwok-Tung Lu
Feb 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ian C G WeaverMoshe Szyf
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jacek DebiecJoseph E Ledoux
Mar 15, 2006·Trends in Endocrinology and Metabolism : TEM·Charles DeBattista, Joseph Belanoff
Mar 17, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maria H MilekicCristina M Alberini
Mar 28, 2006·Current Opinion in Neurobiology·Yadin Dudai
Apr 18, 2006·Biological Psychiatry·Mark E BoutonStephen Maren
Jun 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·György KemenesUli Müller
Aug 3, 2006·Learning & Memory·Paul W FranklandAlcino J Silva
Aug 8, 2006·Annals of the New York Academy of Sciences·Melinda M Miller, Bruce S McEwen
Aug 8, 2006·Annals of the New York Academy of Sciences·Anja Siegmund, Carsten T Wotjak
Aug 8, 2006·Annals of the New York Academy of Sciences·Rachel YehudaDennis S Charney

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Citations

Oct 12, 2012·Psychopharmacology·Irit Akirav, Mouna Maroun
Jul 18, 2012·Molecular Psychiatry·R Sah, T D Geracioti
Jan 1, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Silvia Gabriela BustosVíctor Alejandro Molina
Aug 9, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karine GamacheKarim Nader
May 3, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cristina A J SternLeandro J Bertoglio
Jun 3, 2010·Learning & Memory·Elizaveta V Muravieva, Cristina M Alberini
May 13, 2010·Reviews in the Neurosciences·Jelena Radulovic, Natalie C Tronson
Feb 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amy A ArguelloCristina M Alberini
Feb 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maria Carmen IndaCristina M Alberini
Mar 29, 2011·Stress : the International Journal on the Biology of Stress·Saeed NikzadSaeed Haghighi
Aug 11, 2012·Progress in Neurobiology·Antoine BesnardSerge Laroche
Feb 22, 2012·Neuroscience and Biobehavioral Reviews·Barbara A Sorg
Jul 9, 2011·Neuropharmacology·Thomas Steckler, Victoria Risbrough
Jul 6, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ester Mayumi NinomiyaRoberto Andreatini
Sep 1, 2009·The Psychiatric Clinics of North America·Arieh Y Shalev
Oct 9, 2015·Neuron·Joseph E DunsmoorElizabeth A Phelps
Dec 23, 2014·Neurobiology of Stress·Candace M Raio, Elizabeth A Phelps
Jun 3, 2014·Psychoneuroendocrinology·Marieke G N BosMerel Kindt
Oct 12, 2013·Neurobiology of Learning and Memory·Charles Finsterwald, Cristina M Alberini
Feb 15, 2015·Neurobiology of Learning and Memory·Ulrike RimmeleJan Born
Apr 30, 2015·Journal of the American Psychoanalytic Association·Cristina M Alberini
Apr 30, 2014·Behavioural Pharmacology·E J Marijke AchterbergLouk J M J Vanderschuren
Mar 11, 2020·Frontiers in Behavioral Neuroscience·Eloise J KuijerAmy L Milton
May 26, 2018·Journal of Molecular Neuroscience : MN·Xu WangChen Bian
Sep 13, 2020·International Journal of Molecular Sciences·Lauren Bellfy, Janine L Kwapis
Jul 17, 2014·Behavioural Pharmacology·Miao-Kun Sun, Daniel L Alkon
Aug 21, 2012·Learning & Memory·Pascale Gisquet-Verrier, David C Riccio
Dec 18, 2013·Learning & Memory·Cristina A J SternLeandro J Bertoglio

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