Preclinical Comparison of Mechanistically Different Antiseizure, Antinociceptive, and/or Antidepressant Drugs in a Battery of Rodent Models of Nociceptive and Neuropathic Pain

Neurochemical Research
Misty D SmithKaren S Wilcox

Abstract

The series of experiments herein evaluated prototype drugs representing different mechanisms of antiseizure, antinociceptive or antidepressant action in a battery of preclinical pain models in adult male CF#1 mice (formalin, writhing, and tail flick) and Sprague Dawley rats partial sciatic nerve ligation (PSNL). In the formalin assay, phenytoin (PHT, 6 mg/kg), sodium valproate (VPA, 300 mg/kg), amitriptyline (AMI, 7.5 and 15 mg/kg), gabapentin (GBP, 30 and 70 mg/kg), tiagabine (TGB, 5 and 15 mg/kg), and acetominophen (APAP, 250 and 500 mg/kg) reduced both phases of the formalin response to ≤ 25% of vehicle-treated mice. In the acetic acid induced writhing assay, VPA (300 mg/kg), ethosuximide (ETX, 300 mg/kg), morphine (MOR, 5 & 10 mg/kg), GBP (10, 30, and 60 mg/kg), TGB (15 mg/kg), levetiracetam (LEV, 300 mg/kg), felbamate (FBM, 80 mg/kg) and APAP (250 mg/kg) reduced writhing to ≤ 25% of vehicle-treated mice. In the tail flick test, MOR (1.25-5 mg/kg), AMI (15 mg/kg) and TGB (5 mg/kg) demonstrated significant antinociceptive effects. Finally, carbamazepine (CBZ, 20 and 50 mg/kg), VPA, MOR (2 and 4 mg/kg), AMI (12 mg/kg), TPM (100 mg/kg), lamotrigine (LTG, 40 mg/kg), GBP (60 mg/kg), TGB (15 mg/kg), FBM (35 mg/kg), and APAP (250 ...Continue Reading

References

Nov 1, 1978·Annals of Neurology·A I Basbaum, H L Fields
Oct 1, 1992·Pain·A TjølsenK Hole
Feb 1, 1990·Pain·Helen Wheeler-AcetoAlan Cowan
Feb 1, 1968·British Journal of Pharmacology and Chemotherapy·H O CollierC Schneider
Aug 1, 1969·The Journal of Pharmacy and Pharmacology·W L DeweyJ F Howes
Jan 24, 1997·Neuroscience Letters·N ShimoyamaK J Elliott
Apr 18, 1997·European Journal of Pharmacology·J C HunterD J Fontana
Jun 17, 1999·Lancet·C J Woolf, R J Mannion
Jun 10, 2000·Science·C J Woolf, M W Salter
Jun 28, 2000·The Clinical Journal of Pain·M M Backonja
Jan 17, 2002·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·V NovakJ R Mendell
Mar 13, 2002·European Journal of Pain : EJP·Anthony H DickensonRie Suzuki
May 22, 2002·Molecular Pharmacology·Anders A JensenHans Bräuner-Osborne
Aug 17, 2002·The Journal of Pharmacology and Experimental Therapeutics·Tinna M LaughlinAngela K Birnbaum
Sep 11, 2002·Neurology·Misha-Miroslav Backonja
Feb 28, 2003·Anesthesiology·Yi FengWilliam D Willis
Jul 25, 2003·European Journal of Pharmacology·Denis ArdidAlain Eschalier
Aug 26, 2003·Advanced Drug Delivery Reviews·Lili X Wang, Zaijie Jim Wang
Nov 5, 2003·CNS Drugs·Gary McCleane
Apr 13, 2004·Neuroreport·Isabelle NiespodzianyDoru Georg Margineanu
Jun 23, 2004·Nature Reviews. Neuroscience·Michael A Rogawski, Wolfgang Löscher
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Berkley A LynchBruno Fuks
Jul 28, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Padi S V SatyanarayanaShrinivas K Kulkarni
Oct 21, 2004·The Journal of Pharmacology and Experimental Therapeutics·Carrie K JonesHarlan E Shannon
Dec 31, 2004·QJM : Monthly Journal of the Association of Physicians·D K KocharN Rawat

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Citations

Jul 27, 2017·Journal of Natural Products·Zhenjian LinEric W Schmidt
Mar 28, 2018·The Journal of Pharmacy and Pharmacology·Roberta Gonçalves AnversaLucielli Savegnago
Jul 11, 2018·The Journal of Pharmacology and Experimental Therapeutics·Nayereh Ghoreishi-HaackJoseph R Moskal
Oct 17, 2019·Molecular Pain·Solomiya TsymbalyukJ Marc Simard
May 31, 2019·Current Medicinal Chemistry·Maria Cristina CaroleoErika Cione
Aug 4, 2019·The Journal of Pharmacology and Experimental Therapeutics·Stacey MeekerMelissa Barker-Haliski
Dec 6, 2019·Peptides·Richard J Bodnar

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