Preclinical dosimetry: exploring the use of small animal phantoms.

Radiation Oncology
Emma R BiglinKaren J Kirkby

Abstract

Preclinical radiotherapy studies using small animals are an indispensable step in the pathway from in vitro experiments to clinical implementation. As radiotherapy techniques advance in the clinic, it is important that preclinical models evolve to keep in line with these developments. The use of orthotopic tumour sites, the development of tissue-equivalent mice phantoms and the recent introduction of image-guided small animal radiation research platforms has enabled similar precision treatments to be delivered in the laboratory.These technological developments, however, are hindered by a lack of corresponding dosimetry standards and poor reporting of methodologies. Without robust and well documented preclinical radiotherapy quality assurance processes, it is not possible to ensure the accuracy and repeatability of dose measurements between laboratories. As a consequence current RT-based preclinical models are at risk of becoming irrelevant.In this review we explore current standardization initiatives, focusing in particular on recent developments in small animal irradiation equipment, 3D printing technology to create customisable tissue-equivalent dosimetry phantoms and combining these phantoms with commonly used detectors.

References

Jan 1, 1978·Acta Radiologica: Oncology, Radiation, Physics, Biology·J J BroerseK J Puite
Jan 1, 1996·Physics in Medicine and Biology·U SchneiderA Lomax
Nov 9, 2006·Medical Physics·Strahinja StojadinovicPerry W Grigsby
Jul 22, 2008·International Journal of Radiation Oncology, Biology, Physics·John WongTheodore L DeWeese
Sep 10, 2008·Medical Physics·Li WuQian Liu
Oct 30, 2008·Journal of Experimental & Clinical Cancer Research : CR·Luis-Alberto MedinaMaría-Ester Brandan
Nov 4, 2008·Medical Physics·Erich L KiehlAndrew J Hope
Aug 21, 2009·Journal of Applied Clinical Medical Physics·James F WinslowDavid E Hintenlang
May 28, 2011·Physics in Medicine and Biology·Frank VerhaegenErik Tryggestad
Oct 4, 2011·International Journal of Radiation Biology·Terry YoshizumiJ Daniel Bourland
Apr 12, 2012·Physics in Medicine and Biology·Wilfred NgwaRoss I Berbeco
Oct 25, 2012·Health Physics·Ross McGurkZeljko Vujaskovic
Mar 30, 2013·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·C NobletG Delpon
Mar 19, 2014·Zeitschrift für medizinische Physik·Frank VerhaegenDaniela Trani
Aug 16, 2014·Zeitschrift für medizinische Physik·Falk TillnerWolfgang Enghardt
Nov 13, 2014·The British Journal of Radiology·K T ButterworthF Verhaegen
Apr 11, 2015·Physics in Medicine and Biology·D WelchD J Brenner
May 13, 2015·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·M JermoumiW Ngwa
Jan 1, 2013·Journal of Research of the National Institute of Standards and Technology·Marc DesrosiersHelen Stone
Jan 16, 2016·Radiation Research·Kurt H PedersenLarry A DeWerd
Feb 1, 2017·Radiation Research·David WelchDavid J Brenner
Jun 15, 2017·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·O L DancewiczJ V Trapp
Jul 16, 2017·Medical Physics·Séverine RossommeHugo Palmans
Nov 6, 2017·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Takeshi KamomaeShinji Naganawa
Nov 28, 2017·Medical Physics·Marie VanstalleDavid Brasse
Dec 23, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Frank VerhaegenDietmar Georg
Sep 6, 2018·Physics in Medicine and Biology·Haozhao ZhangJianfeng Qiu

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Methods Mentioned

BETA
X-ray
irradiators

Software Mentioned

FLUKA
GEANT4

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