Preclinical Evaluation and Pilot Clinical Study of Al18 F-PSMA-BCH for Prostate Cancer PET Imaging

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Teli LiuZhi Yang

Abstract

Prostate-specific membrane antigen (PSMA)-targeted radioligands have played an important role in the diagnosis of prostate cancer. In this study, we developed an Al18F-labeled radiotracer and evaluated its potential for prostate cancer imaging. Methods: Al18F-PSMA-BCH (BCH is Beijing Cancer Hospital) was efficiently prepared manually. The binding affinity to PSMA was evaluated in vitro using the 22Rv1 (PSMA-positive) cell line. Small-animal PET imaging, biodistribution studies of Al18F-PSMA-BCH in mice bearing 22Rv1 and PC-3 (PSMA-negative) xenografted tumors, and a comparison with 68Ga-PSMA-617 in mice bearing LNCaP tumors were performed. PET/CT imaging was performed on 11 newly diagnosed prostate cancer patients at 1 and 2 h after injection. Biodistribution and preliminary efficacy were evaluated, and radiation dosimetry was estimated using OLINDA/EXM 2.0 software. Results: Al18F-PSMA-BCH was prepared within 30 min and was found to bind to PSMA with a dissociation constant of 2.90 ± 0.83 nM. Small-animal PET imaging of Al18F-PSMA-BCH could clearly differentiate 22Rv1 tumors from PC-3 tumors, as confirmed by ex vivo biodistribution data (7.87% ± 2.37% and 0.54% ± 0.22% injected dose/g at 1 h in 22Rv1 and PC-3 tumors, respectiv...Continue Reading

References

May 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ronnie C MeaseMartin G Pomper
Aug 3, 2011·Bioconjugate Chemistry·Christopher A D'SouzaDavid M Goldenberg
Nov 2, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ying ChenMartin G Pomper
Jun 5, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Shawn M HillierJohn W Babich
Jun 19, 2013·Oral Oncology·Vincent Lai, Pek Lan Khong
Apr 18, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Martina BenešováMatthias Eder
May 28, 2015·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Markus DietleinBernd Neumaier
Jun 23, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Stefano BoschiKen Herrmann
Jul 16, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Naoya HaradaHideo Saji
Aug 26, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Johannes SchwenckChristian la Fougère
Oct 30, 2016·Expert Review of Molecular Diagnostics·Martin BarrioKen Herrmann
Oct 4, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ali Afshar-OromiehUwe Haberkorn
Oct 4, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Steven P RoweMartin G Pomper
Oct 8, 2016·Cancer Biotherapy & Radiopharmaceuticals·Bernhard GrubmüllerSiroos Mirzaei
Oct 30, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jens CardinaleKlaus Kopka
Nov 9, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Mike SathekgeChristophe Van de Wiele
Nov 17, 2016·European Journal of Nuclear Medicine and Molecular Imaging·James KellyJohn W Babich
Nov 28, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Frederik L GieselC Kratochwil
Dec 3, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Felix DietleinMarkus Dietlein
Dec 30, 2016·Clinical Nuclear Medicine·Mico ChanJennifer Turner
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 8, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ali Afshar-OromiehUwe Haberkorn
Jan 11, 2017·Clinical Nuclear Medicine·Benjamin NotoNemanja Avramovic
Jan 31, 2017·Clinical Genitourinary Cancer·Frederik L GieselBoris A Hadaschik
Apr 30, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Maurits WondergemIgle J de Jong
Jul 9, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sarah M SchwarzenboeckMatthias Eiber
Sep 28, 2017·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Ehab Al-MomaniSamuel Samnick
Oct 21, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·David BirnieRob Beanlands
Mar 15, 2018·Nuklearmedizin. Nuclear Medicine·Christian FilssFelix M Mottaghy
May 3, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Chen LiuZhi Yang

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Citations

Dec 13, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Gongjun YuanGanghua Tang
Jul 13, 2019·Annals of Nuclear Medicine·Citra R A P PalangkaYoshito Tsushima
Mar 20, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Motoki NishimuraKei Yamada
Aug 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cyril FersingBenjamin Guillet
Dec 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Di XiaoJunbo Zhang
Jan 5, 2021·Frontiers in Molecular Biosciences·Teli LiuZhi Yang
May 10, 2021·European Journal of Medicinal Chemistry·Yong HuangKongzhen Hu
Dec 22, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Alexander WurzerHans-Jürgen Wester
Jun 25, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Shuailiang WangZhi Yang
Jun 26, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Teli LiuZhi Yang
Aug 27, 2021·EJNMMI Radiopharmacy and Chemistry·Stephen J Archibald, Louis Allott
Aug 29, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Xiaojiang DuanXing Yang

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