Preclinical evaluation of an innovative anti-TAM approach based on zoledronate-loaded erythrocytes

Drug Delivery and Translational Research
Raffaella SabatinoLuigia Rossi

Abstract

In tumor microenvironment, tumor-associated macrophages (TAMs) are implicated in cancer sustainment, metastasis, and drug resistance, raising a growing interest as targets in cancer therapy. Since the bisphosphonate zoledronate has proven to affect TAMs' functions, the anti-tumor effect of single or repeated administrations of red blood cells (RBCs) encapsulating zoledronate was evaluated in a mouse model of mammary carcinoma. The obtained results showed that loaded RBCs, but not free zoledronate, caused a significant (p < 0.01) and time-lasting reduction of TAMs' extent in tumor mass of Balb/C mice inoculated with murine mammary carcinoma T41 cells; in addition, a significant reduction (p < 0.05) of tumor growth rate has been obtained only following repeated administrations of zoledronate-loaded RBCs. The anti-tumor effect was secondary to the early depletion of spleen macrophages. Moreover, by assessing the IgG2a/IgG1 ratio, a prevalence of Th1 cytotoxic response in tumor-bearing mice receiving zoledronate by means of RBCs has been observed. These encouraging findings provide further evidence for the central role played by macrophages in tumor setting and highlight the suitability of zoledronate-loaded RBCs as pharmacological...Continue Reading

References

Jan 11, 1990·Annual Review of Immunology·F D FinkelmanW E Paul
Apr 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M G CecchiniP H Cooper
Oct 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M J RogersR G Russell
Jan 5, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S DerenneR Bataille
Nov 25, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·O FromigueJ J Body
Jan 5, 2002·Pharmaceutical Research·H MönkkönenJ Mönkkönen
Sep 24, 2002·Current Molecular Medicine·Gideon A Rodan, Alfred A Reszka
Feb 6, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Julie C Frith, Michael J Rogers
Jan 7, 2004·Nature Reviews. Cancer·Jeffrey W Pollard
Jul 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Toru HiragaToshiyuki Yoneda
Sep 13, 2006·Cancer Metastasis Reviews·Alberto MantovaniAntonio Sica
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anke J RoelofsMichael J Rogers
Dec 13, 2006·Biochemical Pharmacology·M F MoreauD Chappard
Jan 26, 2007·Nature Reviews. Cancer·Ignacio MeleroLieping Chen
May 4, 2007·The New England Journal of Medicine·Dennis M BlackUNKNOWN HORIZON Pivotal Fracture Trial
May 4, 2007·The New England Journal of Medicine·Steven R CummingsDennis M Black
Sep 20, 2007·The New England Journal of Medicine·Kenneth W LylesUNKNOWN HORIZON Recurrent Fracture Trial
Apr 25, 2008·Current Protocols in Immunology·B A Pulaski, S Ostrand-Rosenberg
Aug 13, 2008·Journal of the National Cancer Institute·Penelope D OttewellIngunn Holen
Mar 14, 2009·Nature Reviews. Immunology·Jeffrey W Pollard
Apr 8, 2010·Cell·Bin-Zhi Qian, Jeffrey W Pollard
Apr 22, 2010·Calcified Tissue International·Bo Abrahamsen
Jun 24, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wei ZhangZhao-You Tang
Jul 29, 2010·British Journal of Cancer·J D VeltmanJ G J V Aerts
Dec 24, 2010·Breast Cancer Research : BCR·Ingunn Holen, Robert E Coleman
Feb 12, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elisabeth V GigerJean-Christophe Leroux
Feb 16, 2013·Cancer Cell·Giovanni GermanoPaola Allavena
Feb 20, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hilary ShmeedaAlberto Gabizon
Aug 22, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Min DaiKarl Erik Hellstrom
Mar 11, 2015·The Journal of Experimental Medicine·Alberto Mantovani, Paola Allavena
Dec 1, 2015·Pharmacology & Therapeutics·Heleen H Van AckerViggo F Van Tendeloo
Apr 14, 2016·Molecular Pharmaceutics·Mengmeng NiuZhengrong Cui
May 21, 2016·Anti-cancer Agents in Medicinal Chemistry·Jie ZhuWei Li
Jan 21, 2017·Journal of Cellular Biochemistry·Muhammad TariqBo Yang

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Jun 18, 2021·Nano-micro Letters·Qinjun ChenChen Jiang

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BETA
ELISA

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