Preclinical evaluation of degradation kinetics and elemental mapping of first- and second-generation bioresorbable magnesium scaffolds

EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
Michael JonerRon Waksman

Abstract

Because vascular restoration therapy using bioresorbable vascular scaffolds (BRS) remains an appealing concept to restore vasoreactivity, an understanding of biodegradation remains paramount during preclinical testing. We therefore aimed to investigate the qualitative and temporal course of degradation of magnesium alloy-based bioresorbable vascular scaffolds in juvenile swine. Qualitative characterisation of biodegradation was performed in 41 DREAMS 1G up to three years, while degradation kinetics were acquired in 54 DREAMS 2G implanted into porcine coronary arteries for 28, 90 and 180 days, one and two years. Assessment of end product composition was achieved in DREAMS 2G at 180 days. Myocardium was examined, while an OCT attenuation score was derived at strut level from 180 days to two years in DREAMS 2G. Degradation of DREAMS entails two corrosive phases. At one year, 94.8% of the magnesium was bioabsorbed in DREAMS 2G and, at two years, magnesium was completely replaced by amorphous calcium phosphate. Von Kossa staining revealed variable peri-strut mineralisation at all time points and only small focal myocardial emboli observed in one animal in the 180 days cohort. Strut discontinuity density was low at 28 days (0.5±0.57 ...Continue Reading

References

Jun 5, 2007·Lancet·Raimund ErbelUNKNOWN PROGRESS-AMS (Clinical Performance and Angiographic Results of Coronary Stenting with Absorbable Metal Stents) Investigators
May 26, 2009·JACC. Cardiovascular Interventions·Ron WaksmanUNKNOWN PROGRESS-AMS (Clinical Performance Angiographic Results of Coronary Stenting with Absorbable Metal Stents) Investigators
May 18, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Eric WittchowMarlen Braune
Sep 5, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Stephan WindeckerAdam Witkowski

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Citations

Jul 3, 2019·Advanced Materials·Arne BiesiekierskiCuie Wen
Mar 11, 2019·Journal of Neurointerventional Surgery·Basil Erwin GrüterDaniel Coluccia
Feb 6, 2020·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Yoshinobu Onuma, Patrick W Serruys
Feb 26, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Michael HaudeRon Waksman
Feb 26, 2020·Circulation. Cardiovascular Interventions·Yasushi UekiMichael Joner
May 6, 2020·European Heart Journal Supplements : Journal of the European Society of Cardiology·Tobias LenzMichael Joner
Dec 11, 2019·Journal of Clinical Medicine·Mateusz P JeżewskiMarek Postuła
Sep 18, 2020·Science and Technology of Advanced Materials·Sachiko HiromotoTakaya Akashi
Dec 14, 2018·Nature Reviews. Cardiology·Hiroyuki JinnouchiAloke V Finn
Jan 3, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Roman Menze, Eric Wittchow
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Sachiko HiromotoKotaro Doi

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