Preclinical investigation of ab interno trabeculectomy using a novel dual-blade device

American Journal of Ophthalmology
Leonard K SeiboldMalik Y Kahook


To evaluate the effects of a novel ab interno trabeculectomy device on human trabecular meshwork (TM). Laboratory evaluation. The TM from human cadaveric corneal rim tissue was incised using 3 instruments: (1) novel dual-blade device; (2) microvitreoretinal (MVR) blade; and (3) Trabectome. Tissue samples underwent histologic processing and comparative analyses. Subsequently, human eye perfusion studies were performed to evaluate intraocular pressure (IOP)-lowering effects of each device. Main outcome measures were degree of TM removal by histology and IOP in a perfusion model. The MVR blade exhibited minimal removal of TM and obvious injury to the adjacent sclera. The Trabectome removed a large portion of the central TM, but leaflets of residual tissue remained and thermal injury was noted in all samples. The dual-blade device achieved a more complete removal of TM without injury to surrounding tissues. All devices resulted in statistically significant lowering of IOP during perfusion model studies. MVR blade treatment across 170.0 ± 14.1 degrees of TM resulted in a decrease of IOP from 18.5 ± 1.9 mm Hg to 12.8 ± 2.2 mm Hg (P < .01). Trabectome treatment across 117.5 ± 12.6 degrees resulted in a decrease of IOP from 18.8 ± 1.7 ...Continue Reading


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Related Concepts

Physiologic Intraocular Pressure
Tissue Donors
Trabecular Meshwork Structure
Aqueous Humor
Physiologic Intraocular Pressure
Medical Devices
Blades (Device)

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