DOI: 10.1101/456210Oct 29, 2018Paper

Preclinical Modeling of Exposure to a Global Marine Bio Contaminant: Effects of In Utero Domoic Acid Exposure on Neonatal Behavior and Infant Memory

BioRxiv : the Preprint Server for Biology
Kimbery S GrantThomas M Burbacher


Domoic Acid (DA) is a naturally-occurring marine neurotoxin that is increasingly recognized as an important public health issue. Prenatal DA exposure occurs through the maternal consumption of contaminated shellfish/finfish. To better understand the fetal risks associated with DA, we initiated a longitudinal, preclinical study focused on the reproductive and developmental effects of chronic, low-dose oral DA exposure. To this end, 32 adult female Macaca fascicularis monkeys were orally dosed with 0, 0.075 or 0.15 mg/kg/day DA on a daily basis throughout breeding and pregnancy. The doses included the proposed human Tolerable Daily Intake (TDI) (0.075 mg/kg/day) for DA. Adult females were bred to nonexposed males. To evaluate behavioral development during early infancy, offspring were administered a neonatal exam modeled after the human Neonatal Behavior Assessment Scale and a series of visual recognition memory problems. Results indicated that DA does not impact early survival reflexes or responsivity to the environment during the neonatal period. Findings from recognition memory tests showed that exposed and control infants demonstrated robust novelty scores when test problems were relatively easy to solve. However, infants in ...Continue Reading

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