Preclinical mouse models for assessing axial compression of long bones during exercise

BoneKEy Reports
Vincent StadelmannNicolas Bonnet

Abstract

The aim of this laboratory method is to describe two approaches for the investigation of bone responses to mechanical loading in mice in vivo. The first is running exercise, because it is easily translatable clinically, and the second is axial compression of the tibia, because it is precisely controllable. The effects of running exercise, and in general physical activity, on bone tissue have been shown to be both direct through mechanical loading (ground impact and muscle tension) and indirect through metabolic changes. Therefore, running exercise has been considered the most convenient preclinical model for demonstrating the general idea that exercise is good for bone health, either early in age for increasing peak bone mass or later in age by slowing down bone loss. However, numerous combinations of protocols have been reported, which makes it difficult to formulate a simple take-home message. This laboratory method also provides a detailed description of in vivo direct mechanical axial compression of the mouse tibia. The effects of mechanical loading depend on the force (strain), frequency, waveform and duration of application, and they range from bone anabolism with low bone remodeling, inducing lamellar bone accumulation, ...Continue Reading

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Citations

Sep 12, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Russell P MainBettina M Willie
Jul 25, 2017·Biomechanics and Modeling in Mechanobiology·Ariane ScheurenRalph Müller
Oct 14, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Maude GerbaixSerge Ferrari

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