PMID: 8610532Jan 1, 1995Paper

Preclinical pharmacokinetics and general toxicology of iodixanol

Acta Radiologica. Supplementum
I F HeglundE Holtz

Abstract

To document the safety of iodixanol and to assess its pharmacokinetic properties, extensive tests have been performed. Iodixanol was rapidly excreted, mainly via the kidneys, with a plasma half-life in rats and monkeys of 25 and 76 mins, respectively. The pharmacokinetic data were consistent with an extracelleular distribution of iodixanol. During the 24 hours post-dosing, the urinary excretion was from 72 to 100% in rats, and 78% in monkeys. Biliary excretion was 1.5% during the first 4 hours in rats. Fecal excretion was about 7% in rats and 0.8% in monkeys over the first 24 hours after injection. Approximately 0.5 and 1% of the dose was found in the kidneys of rats and monkeys, respectively, 24 hours after dosing. Acute toxicity of iodixanol in rats was low, with an LD(50) greater than 21 g I/kg. In mice the LD(50) was 21 g I/kg and the approximated median lethal dose (ADL(50)) was found to range from 15 to 21 g I/kg. A single dose of 1 and 3 g I/kg was well tolerated in monkeys. As for the other roentgen contrast media, a reversible, dose-related, vacuolation of the proximal tubules in the kidneys was seen in the acute and subacute studies in rats and monkeys. No relationship was seen between the vacuolation and kidney funct...Continue Reading

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Citations

Jan 1, 1996·European Radiology·J O Karlsson
Aug 29, 2012·American Journal of Veterinary Research·Rieko KatayamaKazuhisa Furuhama
Oct 8, 2013·Rapid Communications in Mass Spectrometry : RCM·Erlend Hvattum, Hanno Priebe
Apr 14, 2015·The Journal of Veterinary Medical Science·Ryosuke IwamaKazuhisa Furuhama
Aug 27, 2015·American Journal of Veterinary Research·Yui SasakiKazuhisa Furuhama
Sep 5, 2014·Animal Science Journal = Nihon Chikusan Gakkaihō·Isao MurayamaKazuhisa Furuhama
Jul 8, 2014·The Journal of Veterinary Medical Science·Ryosuke IwamaHiroshi Satoh
Jul 11, 1998·Investigative Radiology·M WasakiM Gemba
Dec 21, 2004·European Radiology·Judith A W WebbUNKNOWN Members of Contrast Media Safety Committee of European Society of Urogenital Radiology (ESUR)
Jun 1, 1997·Investigative Radiology·K J Berg, J A Jakobsen
Aug 22, 2002·The Journal of Eukaryotic Microbiology·William V EversonH D Alan Lindquist
Jul 23, 2011·The Journal of Veterinary Medical Science·Kyoko ImaiKazuhisa Furuhama
May 23, 2015·Journal of Applied Toxicology : JAT·Hiroshi SatohKazuhisa Furuhama
Aug 30, 2014·Physiological Reports·Yui SasakiKazuhisa Furuhama
Jun 12, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ekaterina KoshevayaPavel Krivoshapkin

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