Preclinical safety evaluation in rats using a highly purified ethyl ester of algal-docosahexaenoic acid

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
K B HadleyN Salem

Abstract

Preclinical studies have shown that docosahexaenoic acid (DHA) derived from microalgae (DHASCO) is neither mutagenic nor toxic in acute, subchronic or developmental tests. DHASCO, triglyceride oil from the fermentation of Crypthecodinium cohnii, contains 40-50% (400-500 mg/g) of DHA by weight. Martek Biosciences Corporation has developed a concentrated ethyl ester of DHA (900 mg/g) from DHASCO (MATK-90). A 90-day subchronic safety study with a one-month recovery period using Sprague-Dawley rats included clinical observations, ophthalmic examination, hematology, clinical chemistry, toxicokinetic evaluation, and pathological assessments. Effects of MATK-90 were compared with those produced from DHASCO and control (corn oil). Doses of MATK-90 (1.3, 2.5 and 5.0 g/kg/day) and DHASCO (5.0 g/kg/day=2g of DHA) were administered once-daily by oral gavage at a volume of 10 mL/kg. The corn oil was also administered by oral gavage (10 mL/kg/day). There were no treatment-related adverse effects in any of the parameters measured at doses of <or= 2.5 g/kg/day of MATK-90 or at 5.0 g/kg/day of DHASCO. In the mesenteric lymph node, marked macrophage infiltration was observed in 3 of 19 animals in the 5.0 g/kg/day MATK-90 treatment group and was ...Continue Reading

References

Jul 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K BoswellD J Kyle
Feb 24, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L M ArterburnD J Kyle
Aug 10, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L M ArterburnD J Kyle
Oct 19, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L M ArterburnD J Kyle
Mar 15, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Meng-Chuan HuangJ T Brenna
Apr 15, 2003·Toxicology and Applied Pharmacology·Tsung-Ming ShihJohn H McDonough
Apr 26, 2008·Nature Reviews. Immunology·Charles N SerhanThomas E Van Dyke
Jun 10, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Dennis R HoffmanDeborah A Diersen-Schade
May 4, 2010·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Karin Yurko-MauroUNKNOWN MIDAS Investigators

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Citations

Oct 24, 2013·Nutrition Reviews·Dimitrios G BouzianasApostolos I Hatzitolios
Aug 14, 2012·Regulatory Toxicology and Pharmacology : RTP·Joung-Hyun ParkSuk-Nam Kang
Apr 3, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Irina DahmsNorman Salem
Jan 10, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Morag F Dick, Christopher G Guglielmo

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