Preclinical Safety of the Root Extract of Polygala tenuifolia Willdenow in Sprague-Dawley Rats and Beagle Dogs

Evidence-based Complementary and Alternative Medicine : ECAM
Ki Young ShinHyung Gun Lee

Abstract

The root of Polygala tenuifolia Willdenow has been used for the treatment of insomnia, depression, and amnesia. However, the toxicological properties of the herb have been overlooked, because it has been used for a long time for various purposes. In this study, we evaluated the preclinical safety of the root extract in rats and beagle dogs. First, the acute oral toxicity was tested in both rats and dogs. In the rats, only one female of 2 g/kg died, but no treatment-related death or clinical and gross findings were observed after the administration. No toxicological changes or mortalities related to the test substance were also observed after the administration in the dogs. Although vomiting, discoloration, or hemorrhage was found in some dogs, there were no serious abnormalities. Second, the subchronic toxicity was investigated in the rats. Two animals were found dead in the female group of 1,000 mg/kg/day, but there were no abnormal findings associated with the test substance. There also were no adverse effects on the clinical signs, body weight, and hematological and biochemical findings. Therefore, our results showed that the acute or subchronic toxicity of the root extract of Polygala tenuifolia might not be toxic to rats a...Continue Reading

References

Jan 1, 1986·Journal of Toxicology and Environmental Health·S T WolfordR Ruhren
Oct 1, 1986·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M TobeJ Kanno
Oct 20, 1980·Neuroscience Letters·C L ChernickyC M Ferrario
Jul 22, 1998·Regulatory Toxicology and Pharmacology : RTP·H P Til, A Bär
May 5, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G A Burdock, W G Flamm
Jul 27, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C D HébertR E Conn
Oct 23, 2002·Journal of Neuroscience Research·Cheol Hyoung ParkYoo-Hun Suh
Jul 17, 2004·Biological & Pharmaceutical Bulletin·Yukinobu IkeyaMasaki Aburada
May 12, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R Michael McClainJochen Bausch
Sep 28, 2005·Trends in Pharmacological Sciences·Wen-Yue Jiang
Jan 3, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R A IsbruckerJ Bausch
Feb 20, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Barbara M SchmidtIlya Raskin
Oct 13, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J Xu, J D Z Chen
Feb 13, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M Kaszkin-BettagP W Heger
Jul 11, 2008·Journal of Separation Science·Shao LiuYi-Zeng Liang
Oct 22, 2008·Lancet·Jin-Ling TangKan-Wen Ma
May 12, 2009·Neuroscience Letters·Jun-Young LeeYoo-Hun Suh
May 26, 2009·Toxicology·I M KapetanovicA Lyubimov
Aug 25, 2009·Neuroscience Letters·Ki Young ShinYoo-Hun Suh
Feb 9, 2010·The Journal of Small Animal Practice·C ElwoodK Savary-Bataille
Jun 15, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·P LiuL-Y Kong
Jul 9, 2010·European Journal of Pharmacology·Yu-Jing ChenLin Li
Mar 19, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Amy M BrownawellFederica Montesano
Jun 23, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Celso A R A CostaMirtes Costa
Aug 16, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A GutiérrezS Jiménez
Feb 22, 2012·Journal of Ethnopharmacology·Meng WangJianming Cheng
Feb 22, 2012·Chemistry & Biodiversity·Luiz Carlos KleinValdir Cechinel Filho
Feb 19, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Seo-Ho ShinJong-Choon Kim
Feb 4, 2014·Journal of Ethnopharmacology·Yong-Hoon LeeJong-Koo Kang

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Citations

Feb 11, 2015·Regulatory Toxicology and Pharmacology : RTP·Ki Young ShinHyung Gun Lee

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Methods Mentioned

BETA
urine collection

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