Preclinical studies with the Faure high energy neutron facility: response of pig skin to fractionated doses of fast neutrons (66 MeVp----Be)

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
G BlekkenhorstGerard J M J van den Aardweg

Abstract

The early and late responses of pig skin to fractionated doses of both unfiltered and filtered (i.e. hardened) neutrons using the Faure neutron therapy facility (66 MeVp----Be) were determined and compared with those following fractionated doses with 60Co gamma-rays. Dose-effect curves for the quantal responses of moist desquamation (early epithelial response) and dermal necrosis (late response) were fitted by probit analysis and ED50 values obtained. For a neutron fractionation scheme comprised of 12 fractions in 26 days, and using an unfiltered beam, the ED50 values for moist desquamation and dermal necrosis were 18.67 +/- 2.22 and 22.25 +/- 0.48 Gy, respectively, whereas in the case of the filtered beam, the corresponding ED50 values were 24.78 +/- 1.44 and 23.30 +/- 0.47 Gy. In order to provide a comparison, the values for 24 fractions of 60Co gamma-rays given in 39 days (a clinical protocol used in the Groote Schuur Hospital) were 74.02 +/- 2.92 and 66.72 +/- 1.93 Gy for moist desquamation and dermal necrosis, respectively. For the unfiltered beam, values for the comparative biological effectiveness (CBE) were 3.96 and 3.00 for the early and late skin response, respectively. The corresponding CBE values were for the filter...Continue Reading

References

May 1, 1988·International Journal of Radiation Oncology, Biology, Physics·J W Hopewell, G J van den Aardweg
Oct 1, 1967·The British Journal of Radiology·D K BewleyC J Parnell
Jan 1, 1981·Health Physics·J P Geraci
Apr 1, 1965·The British Journal of Radiology·J F FOWLERJ A SILVESTER

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Citations

Feb 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A Courdi
Aug 1, 1995·Infection and Immunity·M M HobbsT H Kawula

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