Preclinical study of SZ2080 material 3D microstructured scaffolds for cartilage tissue engineering made by femtosecond direct laser writing lithography

Biofabrication
Justinas MačiulaitisRomaldas Mačiulaitis

Abstract

Over the last decade DLW employing ultrafast pulsed lasers has become a well-established technique for the creation of custom-made free-form three-dimensional (3D) microscaffolds out of a variety of materials ranging from proteins to biocompatible glasses. Its potential applications for manufacturing a patient's specific scaffold seem unlimited in terms of spatial resolution and geometry complexity. However, despite few exceptions in which live cells or primitive organisms were encapsulated into a polymer matrix, no demonstration of an in vivo study case of scaffolds generated with the use of such a method was performed. Here, we report a preclinical study of 3D artificial microstructured scaffolds out of hybrid organic-inorganic (HOI) material SZ2080 fabricated using the DLW technique. The created 2.1 × 2.1 × 0.21 mm(3) membrane constructs are tested both in vitro by growing isolated allogeneic rabbit chondrocytes (Cho) and in vivo by implanting them into rabbit organisms for one, three and six months. An ex vivo histological examination shows that certain pore geometry and the pre-growing of Cho prior to implantation significantly improves the performance of the created 3D scaffolds. The achieved biocompatibility is comparabl...Continue Reading

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Citations

Mar 2, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Justinas MačiulaitisRomaldas Mačiulaitis
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Jul 15, 2016·Optics Express·Garrett NelsonMichael Heymann
Aug 14, 2019·Small·Marco Carlotti, Virgilio Mattoli
Aug 5, 2017·Materials·Linas JonušauskasMangirdas Malinauskas
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Jul 15, 2020·Chemical Reviews·Mihyun LeeMarcy Zenobi-Wong

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