Preclinical testing of three South American antivenoms against the venoms of five medically-important Peruvian snake venoms

Toxicon : Official Journal of the International Society on Toxinology
Gavin D LaingR D Theakston

Abstract

World Health Organization (WHO)-recommended preclinical in vivo and in vitro studies were carried out to compare the efficacy of Brazilian, Peruvian and Colombian antivenoms in neutralizing the venom toxins responsible for the lethal, haemorrhagic, necrotizing, coagulant and defibrinogenating effects of five medically-important Peruvian snake venoms. Overall, the Brazilian antivenom was found to be the most effective followed by the Peruvian and Colombian antivenoms. However, it was concluded that all three antivenoms would be acceptable for use in a randomised clinical trial in envenomed humans in Peru.

References

Jan 1, 1989·Toxicon : Official Journal of the International Society on Toxinology·A YarlequeR G Price
Mar 1, 1995·Toxicon : Official Journal of the International Society on Toxinology·G D LaingR D Theakston
Sep 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·R D TheakstonA M Richards
Apr 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·R D G TheakstonE Griffiths

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Citations

May 27, 2014·Toxins·R David G Theakston, Gavin D Laing
Jan 16, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Margaret A O'LearyGeoffrey K Isbister
Feb 19, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Cristian CapitanescuGheorghe Manole
Sep 29, 2009·Toxicology·Geoffrey K Isbister
Jul 17, 2012·Toxicon : Official Journal of the International Society on Toxinology·Francisco S SchneiderCarlos Chávez-Olórtegui
Oct 30, 2008·Bulletin de la Société de pathologie exotique·J EstévezA R de Roodt
May 5, 2020·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Libia SanzCleópatra A S Caldeira
Mar 7, 2018·Toxicon : Official Journal of the International Society on Toxinology·José María Gutiérrez
Jun 2, 2020·Toxicon : Official Journal of the International Society on Toxinology·Carolina Rego RodriguesCarlos Chávez-Olórtegui

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