Preclinical toxicity study of mitomycin C infused into the internal carotid artery of beagle dogs

Selective Cancer Therapeutics
P M KanterC R West

Abstract

Young adult male and female beagle dogs were infused with single doses of 0.5 (2 dogs) or 0.25 mg (5 dogs) Mitomycin C (MMC)/kg body weight directly into the internal carotid artery. Serial hematology and serum chemistry profiles, electrocardiograms and physical observations were made, the animals necropsied at varying times after dosage, and the major organs examined histologically. Results indicate that the dose limiting toxicity of this treatment regimen is myelosuppression. No ocular or neurologic toxicity was detected in any test animal. The findings suggest that infusion of MMC can be safely attempted in humans for the treatment of brain tumors that derive their blood supply from the internal carotid artery.

References

Jan 1, 1978·Acta Radiologica: Oncology, Radiation, Physics, Biology·C Hellekant, L Svanberg
Oct 1, 1977·Acta Radiologica: Therapy, Physics, Biology·W MattssonL Andréasson
Oct 1, 1966·Journal of Neuropathology and Experimental Neurology·O Steinwall, I Klatzo
Jan 1, 1980·Acta Radiologica. Oncology·F von EybenK Jonsson
Jan 1, 1980·Acta Radiologica. Oncology·W MattssonL Hallsten
Nov 23, 1963·JAMA : the Journal of the American Medical Association·G OWENSL BELMUSTO
Mar 1, 1962·Journal of Neurosurgery·D M PERESEW M CHARDACH

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Citations

Dec 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R DuelliS Hoyer

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