Precocious deposition of perineuronal nets on Parvalbumin inhibitory neurons transplanted into adult visual cortex

Scientific Reports
Karen P BradshawSunil P Gandhi

Abstract

The end of the critical period for primary visual cortex (V1) coincides with the deposition of perineuronal nets (PNN) onto Parvalbumin (PV) inhibitory neurons. Recently, we found that transplantation of embryonic inhibitory neurons into adult V1 reinstates a new critical period. Here we used Wisteria Floribunda Agglutinin (WFA) staining to compare the deposition of PNNs onto neurons during normal development and following transplantation at equivalent cell ages. In accord with previous findings, PV and PNN expression increases from negligible levels at postnatal day 14 (P14) to mature levels by P70. In contrast to P14, PNNs are found on transplanted PV neurons by 21 days after transplantation and persist to 105 days after transplantation. This precocious deposition was specific to PV neurons and excluded transplanted neurons expressing Somatostatin. Notably, the onset of PV expression in transplanted inhibitory neurons follows the timing of PV expression in juvenile V1. Moreover, transplantation has no discernible effect on host PNNs. The precocious deposition of PNNs onto transplanted PV neurons suggests that PNN expression identified by WFA does not reflect neuronal maturity and may be an inaccurate marker for transplant-ind...Continue Reading

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Citations

Jun 7, 2020·Proceedings of the National Academy of Sciences of the United States of America·Rebecca K RehTakao K Hensch
Jun 15, 2019·Cellular and Molecular Life Sciences : CMLS·Venkat Raghavan KrishnaswamyIrit Sagi
Dec 8, 2020·Neurobiology of Learning and Memory·Deidre E O'DellDesheng Wang
Nov 3, 2020·Frontiers in Cellular Neuroscience·Nathalie Dehorter, Isabel Del Pino

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