PMID: 40549Jul 15, 1979

Precocious development of cytochrome P-450 in neonatal rat liver after glucocorticoid treatment

The Biochemical Journal
J E Leakey, J R Fouts

Abstract

Intraperitoneal injection of neonatal rats with glucocorticoid hormones causes precocious development of hepatic cytochrome P-450. Glucagon injection fails to stimulate this cytochrome P-450 development. Adult liver cytochrome P-450 is less responsive to glucocorticoid stimulation than is that of neonatal rat liver. Adrenalectomy of prematurely delivered neonatal animals prevents the early postnatal development of cytochrome P-450. Glucocorticoids failed to increase cytochrome P-450 concentrations in foetal rat liver. These findings imply that, although glucocorticoids are mandatory regulatory factors controlling cytochrome P-450 development, they are not themselves the 'trigger' initiating onset of that development.

References

Sep 29, 2004·Neurotoxicology and Teratology·Michael T WilliamsCharles V Vorhees
May 1, 1981·European Journal of Biochemistry·P KremersJ E Gielen
Jul 1, 1980·European Journal of Clinical Pharmacology·O Pelkonen
Sep 1, 1987·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·T Cresteil
Jul 22, 2006·Histochemistry and Cell Biology·Felix Daniel RothCristina Alicia Maldonado
Sep 1, 1991·Human Nature : an Interdisciplinary Biosocial Perspective·C D Laughlin
Feb 1, 1982·Journal of Bioenergetics and Biomembranes·J HoustĕkZ Drahota
Feb 1, 1988·Journal of Bioenergetics and Biomembranes·J E McCarthy

Related Concepts

Tyrosine Aminotransferase
Cytochrome P-450 Oxygenase
Glucagon
Adrenalectomy
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