PMID: 15379428Sep 24, 2004Paper

Precocious, early and fast puberty in males with Chiari I malformation

Journal of Pediatric Endocrinology & Metabolism : JPEM
S StagiR Salti

Abstract

Type I Chiari malformation is a disorder characterized by a displacement of the cerebellar tonsils through the foramen magnum into the upper cervical spinal canal and, contrary to type II Arnold-Chiari malformation, without the presence of myelomeningocele. As described in the literature, patients suffering from Arnold-Chiari malformation with myelomeningocele can frequently present with precocious puberty, whereas only one report shows an association between Chiari I malformation and early puberty. We describe three young males--8.8, 9.4 and 10.4 years old--who were diagnosed with precocious, early and fast puberty associated with type I Chiari malformation. In patients 2 and 3, the reason for diagnostic management recommendation was a rapid progression of pubertal development over one year. None of the patients manifested hypophyseal-hypothalamic axis dysfunction other than sexual precocity. Neurological and ophthalmological examinations were normal in all patients. Our data show that type I Chiari malformation can be considered one of the possible causes for precocious, early and accelerated puberty in male patients, suggesting the need to carry out brain nuclear magnetic resonance imaging in order to investigate the presenc...Continue Reading

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Citations

Apr 26, 2011·Neurological Research·Ruth-Mary deSouzaDavid M Frim
Feb 1, 2018·Korean journal of family medicine·Min Sun KimDae-Yeol Lee

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