Preconception antiphospholipid antibodies and risk of subsequent early pregnancy loss

Lupus
K J GibbinsR Silver

Abstract

Objectives To prospectively estimate the association of preconception antiphospholipid antibodies (aPL) with subsequent pregnancy loss using a cohort design. aPL have been associated with recurrent early pregnancy loss (EPL) prior to 10 weeks in previous case-control studies. Prospective ascertainment of pregnancy loss is challenging, as most women do not seek care prior to EPL. Methods Secondary analysis of the Effects of Aspirin in Gestation and Reproduction trial of preconception low-dose aspirin. Preconception anticardiolipin (aCL) and anti-β2-glycoprotein-I (a-β2-I) were assessed in 1208 women with one or two prior pregnancy losses and no more than two prior live births. Comparison cohorts were defined by positive aPL (+aPL) or negative aPL (-aPL) status. All women were followed for six menstrual cycles while trying to conceive; if successful, they underwent an ultrasound at 6-7 weeks' gestation. EPL was defined as loss prior to 10 weeks' gestation; embryonic loss was loss after visualization of an embryo but prior to 10 weeks; clinical loss was any loss after visualization of an embryo (with or without fetal cardiac activity detected). Results In total, 14/1208 (1%) tested positive for +aPL. 786/1208 (65%) women had posit...Continue Reading

Associated Clinical Trials

Apr 30, 2007·Enrique Schisterman, Enrique Schisterman

References

Oct 10, 1991·The New England Journal of Medicine·C Infante-RivardG E Rivard
Dec 11, 1999·BMJ : British Medical Journal·N J WaldC D Frost
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Aug 3, 2001·Pediatrics·M S KramerUNKNOWN Fetal/Infant Health Study Group of the Canadian Perinatal Surveillance System
Feb 13, 2004·Thrombosis and Haemostasis·Henry RoquéCharles J Lockwood
Aug 17, 2004·Epidemiology·Miguel A HernánJames M Robins
Oct 29, 2010·The New England Journal of Medicine·D Ware BranchRobert M Silver
Jun 16, 2012·Human Reproduction Update·Christine A ClarkKaren A Spitzer
Aug 14, 2012·American Journal of Reproductive Immunology : AJRI·Joanne Kwak-KimZeev Shoham
Aug 8, 2013·Obstetrics and Gynecology·Robert M SilverD Ware Branch
Aug 13, 2013·Paediatric and Perinatal Epidemiology·Enrique F SchistermanRobert W Platt
Jan 14, 2016·Human Reproduction·Sunni L MumfordEnrique F Schisterman

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Citations

Oct 20, 2018·The Journal of Obstetrics and Gynaecology Research·Xin YangJinming Li
Aug 4, 2020·Journal of Translational Autoimmunity·Torie C PlowdenSunni L Mumford
Aug 28, 2021·International Journal of Environmental Research and Public Health·Mei-Lien PanKuo-Hu Chen
Nov 7, 2021·Clinical and Experimental Medicine·Ying XingJing Ma

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Methods Mentioned

BETA
pregnancy tests
SGA

Software Mentioned

SAS

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.