Preconception Hb concentration with risk of spontaneous abortion: a population-based cohort study in over 3·9 million women across rural China.

Public Health Nutrition
Qin XuXu Ma

Abstract

Evidence on the relationship between maternal Hb concentration and spontaneous abortion (SA) risk is limited and conflicting. The purpose of the study was to evaluate whether maternal preconception anaemia or high Hb concentration is associated with risk of SA. A population-based cohort study established between 2013 and 2017. Local maternal and child care service centres in each county. In total, 3 971 428 women aged 20-49 years, who participated in National Free Pre-Pregnancy Checkups Project from 2013 to 2016 and successfully got pregnant before 2017 in rural China. A total of 101 700 (2·56 %) women were recorded having SA, with highest SA rate in women with severe anaemia (4·58 %). Compared with women with Hb of 110-149 g/l, the multivariable-adjusted OR for SA was 1·52 (95 % CI: 1·25, 1·86) for women with Hb < 70 g/l, 0·92 (0·84, 1·01) for 70-99 g/l, 0·80 (0·77, 0·83) for 100-109 g/l, 1·11 (1·08, 1·15) for 150-159 g/l, 1·12 (1·04, 1·20) for 160-169 g/l and 1·02 (0·93, 1·12) for ≥ 170 g/l, respectively. An approximate U-shaped curve for the risk of SA with Hb concentrations was observed when Hb concentrations less than 145 g/l, above which the association plateaued (Pnon-linear < 0·001). Severe anaemia and high Hb concentra...Continue Reading

References

May 1, 1992·The Medical Clinics of North America·M D Williams, M S Wheby
Jul 28, 1988·The New England Journal of Medicine·A J WilcoxB C Nisula
Nov 1, 1987·Geburtshilfe und Frauenheilkunde·L Heilmann
Feb 5, 1997·JAMA : the Journal of the American Medical Association·R NeugebauerM Susser
May 9, 2000·The American Journal of Clinical Nutrition·P J Steer
Jul 4, 2003·The Journal of Nutrition·Shih-Chen ChangFrank R Witter
Feb 15, 2005·Placenta·E Jauniaux, G J Burton
Apr 21, 2005·American Journal of Epidemiology·Rémy SlamaShanna H Swan
Jan 21, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Daniel B Kim-ShapiroMark T Gladwin
Jun 30, 2006·Fertility and Sterility·Virginia J VitzthumBrady West
Jun 26, 2007·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A RenZ Li
Mar 12, 2008·Journal of Perinatal Medicine·Chadakarn Phaloprakarn, Siriwan Tangjitgamol
Jul 7, 2009·International Journal of Epidemiology·Qiaoyi ZhangJohn C Smulian
Aug 8, 2009·Antioxidants & Redox Signaling·Paul W Buehler, Felice D'Agnillo
Sep 11, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gustavo F GonzalesVilma Tapia
Feb 13, 2010·The Journal of Obstetrics and Gynaecology Research·Hiroshige Ishii
Nov 3, 2010·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Chrishantha AbeysenaRohini de A Seneviratne
Dec 21, 2011·Hematology·Leila SekhavatSomaiasadat Hosseinidezoki
Dec 23, 2011·The Journal of Nutrition·Naoko KozukiUNKNOWN Child Health Epidemiology Reference Group
Jun 22, 2012·Demography·Kevin Lang, Ana Nuevo-Chiquero
Jun 28, 2013·BMC Medicine·Elisabeth Clare LarsenNick Macklon
Jan 16, 2014·The Journal of Clinical Endocrinology and Metabolism·Danielle A J M SchoenakerUNKNOWN EURODIAB Prospective Complications Study Group
Mar 31, 2015·European Journal of Medicinal Chemistry·Wen-Jian TangJun Li
Sep 28, 2015·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Lijian Wang
Dec 8, 2015·The International Journal of Risk & Safety in Medicine·L O Buzyan
Apr 14, 2016·BMC Psychiatry·Susil KulathilakaVaruni A de Silva
Oct 27, 2017·The American Journal of Clinical Nutrition·Kathryn G Dewey, Brietta M Oaks

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.