Preconception seminal plasma concentrations of endocrine disrupting chemicals in relation to semen quality parameters among male partners planning for pregnancy

Environmental Research
Melissa M SmarrG M Buck Louis

Abstract

Some non-persistent endocrine disruptors (EDCs) are adversely associated with semen quality and few studies have measured those EDCs in seminal plasma. To find an association between EDCs in seminal plasma and semen quality parameters. Five chemical classes of non-persistent EDCs were quantified in seminal plasma from 339 male partners who participated in a prospective pregnancy study. Bisphenols, benzophenone UV-filters, antimicrobials and phthalate diesters and their monoester metabolites were measured using high performance liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry. Semen samples underwent next day analysis using a standardized protocol for the quantification of 35 endpoints. Linear mixed-effects models of EDCs that were log transformed and rescaled by their standard deviations or dichotomized at the 75th percentile for each exposure and outcomes with covariate adjustment were performed. EDCs in seminal plasma were also assessed relative to clinical reference values of semen quality endpoints using logistic regression or generalized estimating equations. The most consistent findings supporting adverse associations between seminal EDCs and semen quality were observed for some phth...Continue Reading

Citations

Mar 19, 2020·JAMA Dermatology·Andrea C Gore, Barbara Cohn
Jul 30, 2020·International Journal of Toxicology·Priya CherianBart Heldreth
Aug 28, 2020·Toxics·Kajsa Ugelvig PetersenSandra Søgaard Tøttenborg
Apr 10, 2019·Toxics·Yu WangKurunthachalam Kannan
Dec 26, 2018·The Science of the Total Environment·Zhongming BuCong Dong
Jul 28, 2020·Molecular and Cellular Endocrinology·Lara TamburrinoElisabetta Baldi
Apr 8, 2021·Journal of Applied Toxicology : JAT·Carmine MerolaMonia Perugini
Jun 30, 2021·Arhiv za higijenu rada i toksikologiju·Tihana MarićAnna Aghayanian
Nov 23, 2021·The Science of the Total Environment·Aizhen WangRong Zhang

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