PMID: 8993257Jan 1, 1997Paper

Preconditioning and hypothermic cardioplegia protect human heart equally against ischemia

The Annals of Thoracic Surgery
J C ClevelandA H Harken

Abstract

The purpose of this study was to determine whether transient ischemic preconditioning protects human myocardium against normothermic ischemic injury. Isolated human right atrial trabeculae were suspended in an organ bath with oxygenated Tyrode's solution at 37 degrees C and field stimulated at 1 Hz. Developed force was recorded. Trabeculae (Warm I/R) received normoxic perfusion before 45 minutes of normothermic simulated ischemia (hypoxic, substrate-free buffer with pacing at 3 Hz) and 120 minutes of reperfusion. Preconditioned trabeculae (Warm IPC) were subjected to 5 minutes of normothermic simulated ischemia and 10 minutes of perfusion before normothermic simulated ischemia-reperfusion injury. Trabeculae (Cold I/R) were subjected to hypothermic (4 degrees C) ischemia (hypoxic buffer) for 4 hours and 60 minutes of reperfusion (37 degrees C). Preconditioned trabeculae (Cold IPC) were pretreated with 5 minutes of normothermic simulated ischemia before hypothermic ischemia and 60 minutes of reperfusion. At the end of reperfusion, trabeculae were frozen at -70 degrees C and assayed for tissue creatine kinase activity. At the end of reperfusion, warm preconditioned trabeculae (Warm IPC) recovered 51% +/- 5% of baseline developed f...Continue Reading

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Citations

Aug 26, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A Hawaleshka, E Jacobsohn
Jun 7, 2005·The Journal of Surgical Research·Jeffrey M PitcherDaniel R Meldrum
Apr 10, 2003·The Annals of Thoracic Surgery·Hannu J PenttiläKeijo J Peuhkurinen
Feb 4, 1999·The Annals of Thoracic Surgery·R W LandymoreJ H Fris
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Jan 2, 2008·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Y HarderM D Menger
Apr 28, 2005·Journal of Cardiac Surgery·Mustafa BuyukatesHalim Soncul
Jan 15, 2005·Journal of Cardiothoracic and Vascular Anesthesia·Vincent Piriou, Pascal Chiari
Apr 1, 1997·The Journal of Surgical Research·D R MeldrumA Banerjee
Oct 27, 1999·The Journal of Surgical Research·B S CainA H Harken
Oct 18, 2003·Anesthesiology Clinics of North America·Stanton K Shernan
Oct 5, 2006·Current Opinion in Anaesthesiology·Peter Rock, Zhenhai Yao
Jul 1, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·G LiY Li
Jun 11, 1999·The American Journal of Physiology·S L Hale, R A Kloner
Apr 8, 1998·The American Journal of Physiology·D R Meldrum
Nov 16, 2001·Journal of Molecular and Cellular Cardiology·S BesP Athias

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