Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptors.

Proceedings of the National Academy of Sciences of the United States of America
Yumi UekiJohn D Ash

Abstract

Retinal degenerations are a class of neurodegenerative disorders that ultimately lead to blindness due to the death of retinal photoreceptors. In most cases, death is the result of long-term exposure to environmental, inflammatory, and genetic insults. In age-related macular degeneration, significant vision loss may take up to 70-80 years to develop. The protracted time to develop blindness suggests that retinal neurons have an endogenous mechanism for protection from chronic injury. Previous studies have shown that endogenous protective mechanisms can be induced by preconditioning animals with sublethal bright cyclic light. Such preconditioning can protect photoreceptors from a subsequent damaging insult and is thought to be accomplished through induced expression of protective factors. Some of the factors shown to be associated with protection bind and activate the signal transducing receptor gp130. To determine whether stress-induced endogenous protection of photoreceptors requires gp130, we generated conditional gp130 knockout (KO) mice with the Cre/lox system and used light-preconditioning to induce neuroprotection in these mice. Functional and morphological analyses demonstrated that the retina-specific gp130 KO impaired ...Continue Reading

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Citations

Apr 6, 2013·Investigative Ophthalmology & Visual Science·Johnny TangTimothy S Kern
Dec 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ke JiangRoderick R McInnes
Dec 21, 2011·Progress in Retinal and Eye Research·Rong WenPaul A Sieving
Sep 3, 2013·Progress in Retinal and Eye Research·Yusuke MurakamiDemetrios G Vavvas
Nov 24, 2011·Progress in Retinal and Eye Research·Christian Caprara, Christian Grimm
Jun 1, 2016·Frontiers in Pharmacology·Reiko KawaseToshio Tanaka
Sep 25, 2016·Progress in Retinal and Eye Research·Xiaowu GuMichael H Elliott
Nov 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Kun Do RheeXian-Jie Yang
Nov 28, 2017·Cellular and Molecular Neurobiology·Eric J KnottNicolas G Bazan

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