Preconditioning of H2S inhalation protects against cerebral ischemia/reperfusion injury by induction of HSP70 through PI3K/Akt/Nrf2 pathway

Brain Research Bulletin
Kangxiang JiYu Bai

Abstract

It is of great importance to protect the brain against cerebral ischemia and reperfusion (I/R) injury, which leads to excitotoxicity, redox imbalance, inflammation and apoptosis; however, there is currently no effective treatment. The present study aimed to investigate the effect of H2S preconditioning on cerebral I/R injury and its underlying mechanism. The results demonstrated that H2S preconditioning significantly prevented the development of neurological function abnormality, inflammation and oxidative injury in mice as well as cognitive impairment caused by cerebral I/R. H2S preconditioning also suppressed the apoptosis caused by cerebral I/R. Moreover, the protective effect of H2S preconditioning was found to involve heat shock protein 70 (HSP70), in which the PI3K/Akt/Nrf2 pathway was involved. The data showed that H2S preconditioning could protect mice against cerebral I/R injury by the induction of HSP70 and the PI3K/Akt/Nrf2 pathway.

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Citations

Aug 23, 2018·Journal of Cellular Physiology·Yan-Jun SongXian-Bao Wang
Jul 25, 2019·Stroke and Vascular Neurology·Jia JiaJian Cheng
Mar 12, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M M YurinskayaM B Evgen'ev
Jul 7, 2020·Journal of Cellular and Molecular Medicine·Junduo WuHao Wu
Feb 18, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yanwen Li, Shikun Liu
Jul 18, 2018·International Journal of Molecular Medicine·Yajun ChangXiumin Liu
Jan 29, 2019·British Journal of Neurosurgery·Wen-Hua LiJun Ren
Mar 21, 2019·Frontiers in Pharmacology·Lei LiuSylvain Doré
Aug 1, 2019·Experimental and Therapeutic Medicine·Congying ZhaiYan Qu
Oct 23, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Xuan ShiXin Lv
Jan 12, 2021·Oxidative Medicine and Cellular Longevity·Jiaxin ZhangMingyang Zhang
Apr 17, 2021·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Haixia WangJianjun Mu
May 22, 2021·Archives of Biochemistry and Biophysics·Jiechun ZhuGuangdong Yang
Aug 8, 2021·International Journal of Molecular Sciences·Bartosz PomiernyBogusława Budziszewska
Sep 21, 2021·Antioxidants & Redox Signaling·Yaqian HuangHongfang Jin

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