Precordial and epicardial surface potentials during Myocardial ischemia in the pig. A theoretical and experimental analysis of the TQ and ST segments.

Circulation Research
R P Holland, H Brooks

Abstract

The solid angle theorem was used to analyze the relationships between TQ and ST segment deflections recorded from precordial and epicardial locations and the time course, size, shape, and transmural location of the ischemic process in the ventricular myocardium. Mathematical predictions were compared with experimental data from the intact heart. Precordial electrograms obtained in anesthetized close-chest pigs were compared with epicardial electrograms recorded directly from the heart's surface. Various areas of ischemia were produced by occluding large and small coronary artery branches, and the resultant changes in ischemic shape were delineated with Thioflavin S injections and postmortem ultraviolet photography. Formally derived equations and cumulative experimental data were in close agreement, suggesting that in the ischemic ventricle (1) TQ depression always accompanies ST elevation, (2) TQ and ST segment changes in magnitude and polarity are complex functions of ischemic size, shape, and transmural location; (3) precordial electrocardiogram (ECG) ST segment elevation is directly related to ischemic size; and (4) epicardial ECG ST segment elevation is inversely related to ischemic size. It is thus concluded that precordia...Continue Reading

References

Nov 1, 1975·The American Journal of Cardiology·H BrooksL Resnekov
Sep 1, 1974·Journal of Applied Physiology·R HollandH Brooks
Aug 1, 1952·The American Journal of Physiology·B F HOFFMAN, E E SUCKLING
Jan 1, 1954·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·W TRAUTWEINJ DUDEL
May 1, 1957·The American Journal of Physiology·E DONOSOA GRISHMAN
Nov 1, 1963·American Heart Journal·P F SALISBURYP A RIEBEN
Sep 1, 1964·The American Journal of Physiology·E S KIRK, C R HONIG

❮ Previous
Next ❯

Citations

Jan 1, 1978·Intensive Care Medicine·M C Apps, J Tinker
Oct 31, 2007·Medical & Biological Engineering & Computing·Mark PotseAlain Vinet
Mar 1, 1977·The Journal of Surgical Research·P E KarayannacosJ S Vasko
Jun 1, 1995·Journal of the American College of Cardiology·P M Okin, P Kligfield
Jan 13, 2004·Journal of Electrocardiology·David KilpatrickD S Li
Sep 5, 2002·International Journal of Cardiology·Kjell VikenesJan Erik Nordrehaug
Jul 1, 1979·Archives of Environmental Health·L C Becker, E D Haak
Jun 3, 2005·Journal of Cardiopulmonary Rehabilitation·Joy M KaplanPaul Kligfield
Aug 31, 1999·Journal of Cardiovascular Electrophysiology·V RankovicA Kadish
Sep 1, 1979·British Heart Journal·S YusufP Sleight
Mar 1, 1976·The Journal of Clinical Investigation·R P Holland, H Brooks
Nov 1, 1981·Journal of Pharmacological Methods·D C WarltierH L Brooks
Dec 22, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Mark G HoogendijkRuben Coronel
Jul 1, 1977·The American Journal of Cardiology·R P Holland, H Brooks
Jun 1, 1981·The American Journal of Cardiology·B R Chaitman, J S Hanson
Jun 10, 2006·IEEE Transactions on Bio-medical Engineering·Mary C MacLachlanAslak Tveito
Dec 1, 1980·The American Journal of Cardiology·F N NasserC E Harrison
May 13, 2005·IEEE Transactions on Bio-medical Engineering·Mary C MacLachlanGlenn Terje Lines
Feb 1, 1980·American Heart Journal·J S GeddesJ F Pantridge
Oct 1, 1979·Journal of Electrocardiology·J E Madias
Nov 1, 1982·Pacing and Clinical Electrophysiology : PACE·S SiegelS Furman
Mar 1, 1985·American Heart Journal·R E Nitz, P A Martorana
Sep 28, 2015·Clinical Hemorheology and Microcirculation·Eun-Seok ShinJai-Wun Park
Jul 1, 1997·The Journal of Surgical Research·S PremaratneJ J McNamara
Nov 27, 2007·Journal of the American College of Cardiology·Kristian ThygesenUNKNOWN Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction
Mar 31, 1976·The American Journal of Cardiology·M Lesch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.