Precultured and fresh human T-cells suppress the mitogen response of autologous lymphocytes

Immunology Letters
E PócsikP Gergely

Abstract

Human T-lymphocytes, after culture at 37 degrees C for 48 h, suppressed the Con A-induced blastogenesis of fresh autologous lymphocytes. Both Fc gamma receptor-positive and -negative T-cell subsets were active as suppressors. Non-T-cells failed to show such a phenomenon. Similarly, freshly isolated T-cells, and Fc gamma receptor-positive T-lymphocytes also suppressed the blastogenic response. Thus, preculture is not required to obtain "suppressor cells". The suppression of mitogen responses therefore seems to be an inherent property of T-cells.

References

May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S A SchwartzY S Choi
Feb 23, 1975·Nature·C A JanewayE Simpson

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