Precursor-Directed Diversification of Cyclic Tetrapeptidic Pseudoxylallemycins

Chembiochem : a European Journal of Chemical Biology
Huijuan GuoChristine Beemelmanns

Abstract

Cyclic peptides containing non-proteinogenic amino acids often exhibit a broad bioactivity spectrum and many have entered clinical trials with good prospects for drug development. We recently reported the discovery of six cyclic tetrapeptides, pseudoxylallemycins A-F (1-6), from a termite-associated Pseudoxylaria sp. X802. These compounds contain a rare O-homoallenyl-l-tyrosine moiety and show promising antimicrobial activity against the Gram-negative pathogenic bacterium Pseudomonas aeruginosa. To perform more detailed structure-activity studies, we pursued a precursor-directed diversification strategy. Herein, we report the purification, identification, and testing of 21 new pseudoxylallemycin derivatives.

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Citations

Jan 11, 2019·Chembiochem : a European Journal of Chemical Biology·Aleksa Stanišić, Hajo Kries
Apr 4, 2019·Organic & Biomolecular Chemistry·Alan J CameronMargaret A Brimble
Apr 5, 2019·Angewandte Chemie·Fumihiro IshikawaGenzoh Tanabe
May 28, 2019·Chembiochem : a European Journal of Chemical Biology·Fumihiro Ishikawa, Genzoh Tanabe
Mar 28, 2020·Chembiochem : a European Journal of Chemical Biology·Angela SesterMarkus Nett
Apr 26, 2019·Biotechnology Letters·Pengchao ZhaoShuxiao Feng
Mar 27, 2020·Chembiochem : a European Journal of Chemical Biology·Seoung Rak LeeKi Hyun Kim
May 30, 2020·Chembiochem : a European Journal of Chemical Biology·Felix SchalkChristine Beemelmanns
Jan 14, 2021·Chembiochem : a European Journal of Chemical Biology·Ignacio Pérez-Victoria
May 29, 2020·Journal of Natural Products·Julia MoschnyTimo H J Niedermeyer

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