Precursors of functional MHC class I- or class II-restricted CD8alphaalpha(+) T cells are positively selected in the thymus by agonist self-peptides

Immunity
A J LeishmanH Cheroutre

Abstract

The origin and specificity of alphabeta TCR(+) T cells that express CD8alphaalpha have been controversial issues. Here we provide direct evidence that precursors of functional CD8alphaalpha T cells are positively selected in the thymus in the presence of agonist self-peptides. Like conventional positive selection, this agonist selection process requires functional TCR alpha-CPM, whereas it is independent of CD8beta expression. Furthermore, CD8alphaalpha expression on mature, agonist-selected T cells does not imply selection by MHC class I, and CD8alphaalpha(+) T cells can be either class I or class II restricted. Our data define a distinct agonist-dependent, positive selection process in the thymus, and they suggest a function for CD8alphaalpha distinct from the conventional TCR coreceptor function of CD8alphabeta or CD4.

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Citations

Jun 3, 2005·Springer Seminars in Immunopathology·Hilde Cheroutre, Mitchell Kronenberg
Sep 15, 2005·Journal of Clinical Immunology·Claude LambertGenin Christian
Apr 22, 2004·Trends in Immunology·Ken-ichiro SeinoMasaru Taniguchi
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May 1, 2012·Nature Immunology·Leonid A PobezinskyAlfred Singer
May 7, 2013·Nature Immunology·Michael MingueneauShannon Turley
Dec 17, 2005·Nature Immunology·Adrian Hayday
May 28, 2004·Nature Immunology·Albert Bendelac
Sep 22, 2009·Nature Immunology·Hilde CheroutreFlorence Lambolez
Apr 2, 2004·Nature Reviews. Immunology·Hilde Cheroutre, Loui Madakamutil
Jun 18, 2011·Nature Reviews. Immunology·Hilde CheroutreDaniel Mucida
Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Danyvid Olivares-VillagómezLuc Van Kaer
Feb 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Susannah D BarbeeAdrian C Hayday
Apr 12, 2003·The Journal of Experimental Medicine·Taehoon ChunChyung-Ru Wang
Feb 5, 2003·The Journal of Experimental Medicine·Delphine Guy-GrandPierre Vassalli
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