PMID: 6969781Jan 1, 1981Paper

Precursors of murine B lymphocytes. Physical and functional characterization, and distinctions from myeloid stem cells

The Journal of Experimental Medicine
C J PaigeV L Sato

Abstract

The emergence of functional B cells was monitored in irradiated or unirradiated CBA/N recipients of either adult bone marrow or fetal liver from CBA/HT6T6 donors. The cells that are primarily responsible for the generation of B lymphocytes, at least during the first 6 wk, are rapidly sedimenting (4.5-6 mm/h), lack surface immunoglobulin, and are found in both the adult bone marrow and the fetal liver from day 12 onward. These pre-B cells are distinct from the colony-forming unit spleen (CFU-s) as demonstrated by the following criteria: (a) absence from yolk sac (19), (b) lack of correlation between CFU-s number and the ability to generate B cells in fetal liver populations of different ages of gestation, and (c) hybridoma antibodies that significantly inhibited B cell reconstitution but have no effect on CFU-s numbers. The antigen detected by this antiserum is present on both the fetal liver and bone marrow B cell progenitor, although its expression is not restricted to the B lineage. The pre-B cells that we monitor are not homogeneous, however, as both physical and functional differences are found. These observations reinforce our thesis that committed progenitor cells for the humoral immune system are formed early in developm...Continue Reading

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Citations

Apr 1, 1981·Journal of Clinical Immunology·M D Cooper
Jan 1, 1982·Journal of Immunological Methods·C J Paige, H Skarvall
Jan 1, 1984·Developmental and Comparative Immunology·K S Landreth, P W Kincade
Jan 1, 1984·Developmental and Comparative Immunology·E S MedlockP W Kincade
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J I KurlandO N Witte
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J C WeillJ R Pink
Jul 1, 1991·The Journal of Experimental Medicine·C E Müller-Sieburg
Dec 10, 2008·Blood·John E Dick
Mar 1, 1987·International Reviews of Immunology·P W KincadeG Lee
Nov 4, 2015·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Laura LossiAdalberto Merighi
Jan 1, 1982·Annals of the New York Academy of Sciences·P W KincadeG Lee
Jun 30, 1983·Annals of the New York Academy of Sciences·R M ParkhouseS Marshall-Clarke
Jan 1, 1982·Immunological Reviews·J P McKearnJ M Davie
Jan 1, 1982·Immunological Reviews·P W KincadeG Lee
Jul 29, 2016·Seminars in Immunopathology·María Emilia SolanoEva Tolosa
Apr 18, 2015·Toxicologic Pathology·George A ParkerJonathan D Toot
Jun 1, 1981·Immunology Today·P Nieuwenhuis
Jan 1, 1983·Immunology Today·I F McKenzie, H Zola
Dec 3, 2002·Human & Experimental Toxicology·K S Landreth
Dec 12, 2003·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Michael P HolsappleKenneth S Landreth
Sep 1, 1982·European Journal of Immunology·S Marshall-ClarkeR M Parkhouse
Sep 1, 1986·European Journal of Immunology·D KaragogeosH H Wortis
Jun 2, 2020·Frontiers in Immunology·Angelina MimounSébastien Lacroix-Desmazes
Jun 28, 1982·Biochimica Et Biophysica Acta·R Risser

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