Precursors of three unique cysteine-rich peptides from the scorpion Buthus martensii Karsch

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
Shunyi Zhu, Wenxin Li

Abstract

Scorpion venoms contain a large number of small peptides with diverse primary structures and unique pharmacological functions. From a cDNA library prepared from venom glands of the Chinese scorpion Buthus martensii Karsch, clones encoding precursors of three unique cysteine-rich peptides named BmTXKS3, BmTXLP2 and BmAP1 have been isolated and sequenced. These precursors are composed of 54, 94 and 89 amino acids, respectively, containing a signal peptide in their N-termini. Sequence analysis shows that BmTXKS3 and BmTXLP2 are two novel members of a scorpion toxin family sharing cysteine-stabilized alpha-helical folds. BmAP1 possesses a distinctive cystine framework, which is similar to some serine protease inhibitors and the segments of several extracellular proteins.

References

Jun 11, 1986·Nucleic Acids Research·G von Heijne
Feb 1, 1993·The American Journal of Physiology·J A DeBinG R Strichartz
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·P StassensG P Vlasuk
Jul 1, 1997·Nucleic Acids Research·G Edwalds-GilbertC Milcarek
Sep 28, 1998·Protein Engineering·H TamaokiL Moroder
Dec 16, 1998·Science·UNKNOWN C. elegans Sequencing Consortium
Feb 13, 1999·Journal of Protein Chemistry·L A FerreiraI Lebrun
Feb 27, 1999·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·S A AliW Voelter
Jul 30, 1999·Developmental and Comparative Immunology·P BuletD Hoffmann
Sep 22, 1999·European Journal of Biochemistry·L D PossaniJ Tytgat
Jun 20, 2000·Toxicon : Official Journal of the International Society on Toxinology·S Y ZhuX Mao
Aug 10, 2000·European Journal of Biochemistry·A Torres-LariosL D Possani
Jan 14, 2001·The Journal of Biological Chemistry·Y V KorolkovaE V Grishin
Jan 4, 2001·Toxicon : Official Journal of the International Society on Toxinology·M L GarciaG J Kaczorowski

❮ Previous
Next ❯

Citations

Mar 1, 2014·Toxins·Zhijian CaoWenxin Li
Jul 12, 2013·Journal of Toxicology·Bennasr HmedZeghal Khaled Mounir
Jan 3, 2015·Toxicon : Official Journal of the International Society on Toxinology·Ursula Castro de OliveiraInácio de Loiola Meirelles Junqueira-de-Azevedo
May 12, 2012·Toxicon : Official Journal of the International Society on Toxinology·S C ChaiK Jeyaseelan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.