Prediabetes and Alzheimer's Disease

Indian Journal of Pharmaceutical Sciences
V R BitraAnnapurna Akula

Abstract

Aging patients with diabetes are at higher risk of developing Alzheimer's disease. Emerging evidences demonstrate the role of brain insulin resistance, which is a key mediator in prediabetes and diabetes mellitus that may lead to Alzheimer's disease. Insulin and insulin-like growth factors regulate many biological processes such as axonal growth, protein synthesis, cell growth, gene expression, proliferation, differentiation, and development. Among these, the energy metabolism and synaptic plasticity are the major transduction processes regulated by insulin, which are the core objectives for learning and memory. It was also proposed that hyper insulinemia induced insulin resistance results in injury to the central nervous system by the activation of glycogen synthase kinase 3β which is the key ailment in the cognitive decline. Hence, the endogenous brain specific insulin impairments and signaling account for the majority of Alzheimer's abnormalities.

Citations

Jun 4, 2016·International Journal of Molecular Sciences·Stefania Rigacci, Massimo Stefani
Sep 16, 2019·Hormones : International Journal of Endocrinology and Metabolism·Marianna KarvaniD Kapoukranidou
Oct 21, 2016·Expert Review of Neurotherapeutics·Fiorella Casamenti, Massimo Stefani
Sep 11, 2021·Free Radical Biology & Medicine·Owen Davis SandersJayalekshmi Archa Rajagopal

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