Prediabetes and cardiovascular disease risk: A nested case-control study

Atherosclerosis
Huanhuan HuJapan Epidemiology Collaboration on Occupational Health Study Group

Abstract

We aimed to examine the risk of cardiovascular disease (CVD) with persistent prediabetes during the last four years prior to a CVD event in a large occupational cohort in Japan. We performed a nested case-control study using data from the Japan Epidemiology Collaboration on Occupational Health Study. A total of 197 registered cases of CVD were identified and matched individually with 985 controls according to age, sex, and worksite. Prediabetes was defined as fasting plasma glucose 100-125 mg/dL and/or HbA1c 5.7-6.4%. Persistent prediabetes was defined as having prediabetes at years one and four prior to the onset/index date; persistent normoglycemia was similarly defined. Associations between prediabetes and CVD risk were assessed using conditional logistic regression models. Compared with people with persistent normoglycemia over the four years prior to the onset/index date, the unadjusted odds ratio (95% confidence interval) for CVD was 2.88 (1.56, 5.32) for people with persistent prediabetes. After adjusting for BMI, smoking, hypertension, and dyslipidemia assessed four years before the onset/index date, the association was slightly attenuated to an OR (95% confidence interval) of 2.62 (1.31, 5.25). Prediabetes assessed at ...Continue Reading

Citations

Nov 22, 2019·Journal of Occupational Health·Mi XiangUNKNOWN Japan Epidemiology Collaboration on Occupational Health Study Group
Jul 2, 2019·Acta Neuropsychiatrica·Sanmei ChenUNKNOWN Japan Epidemiology Collaboration on Occupational Health Study Group
Jan 15, 2021·Diabetes Care·Zobida IslamUNKNOWN Japan Epidemiology Collaboration on Occupational Health Study Group
Oct 4, 2020·Journal of Psychosomatic Research·Ami FukunagaUNKNOWN Japan Epidemiology Collaboration on Occupational Health Study Group

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