Prediabetes and long-term outcomes in patients with three-vessel coronary artery disease: A large single-center cohort study.

Journal of Diabetes Investigation
Deshan YuanJinqing Yuan

Abstract

Whether detection of prediabetes by routinely testing hemoglobin A1c and fasting plasma glucose in three-vessel disease patients could identify individuals at high risk of future cardiovascular disease events remains unclear. This study evaluated the relationship between different glycemic status and clinical outcomes in this specific population. This study included 8,891 Chinese patients with three-vessel disease. Patients were categorized according to their glycemic status (normoglycemia [NG], n = 3,195; prediabetes, n = 1,978; diabetes mellitus, n = 3,718). The median follow-up time was 7.5 years, during which 1,354 deaths and 2,340 major adverse cardiac and cerebrovascular events occurred. Compared with the NG group, patients in the prediabetes and diabetes mellitus groups had more comorbidities. After adjusting for confounders, the diabetes mellitus group had a higher risk of all-cause death (hazard ratio [HR] 1.36, 95% confidence interval [CI] 1.20-1.53; P < 0.001), cardiac death (HR 1.35, 95% CI 1.14-1.61; P = 0.001) and major adverse cardiac and cerebrovascular events (HR 1.22, 95% CI 1.11-1.34; P < 0.001) compared with the NG group, whereas the prediabetes and NG groups had no significant difference. The diabetes melli...Continue Reading

References

Dec 23, 2006·The Annals of Thoracic Surgery·Whady HuebJosé A F Ramires
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Mar 12, 2010·The New England Journal of Medicine·Manesh R PatelPamela S Douglas
Jun 12, 2012·Lancet·Adam G TabákMika Kivimäki
Jul 17, 2014·BMJ : British Medical Journal·John S Yudkin, Victor M Montori
Aug 8, 2015·Circulation·Caroline S FoxUNKNOWN American Heart Association Diabetes Committee of the Council on Lifestyle and Cardiometabolic Health, Council on Clinical Ca
Jun 28, 2017·JAMA : the Journal of the American Medical Association·Limin WangLinhong Wang
Jan 10, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Marlies M KokLiefke C van der Heijden
Feb 7, 2018·Endocrinology and Metabolism Clinics of North America·Ben Brannick, Sam Dagogo-Jack
Apr 14, 2018·Circulation Research·David H WassermanNancy J Brown
Dec 19, 2018·Diabetes Care·UNKNOWN American Diabetes Association
May 3, 2019·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Sudipta ChattopadhyayThozhukat Sathyapalan

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

SPSS

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