Prediagnosis Use of Statins Associates With Increased Survival Times of Patients With Pancreatic Cancer

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Tsuyoshi HamadaBrian M Wolpin

Abstract

Statin medications, most commonly prescribed to reduce lipid levels and prevent cardiovascular disease, may be associated with longer survival times of patients with cancer. However, the association of statins with outcomes of patients with pancreatic adenocarcinoma is not clear. We analyzed the association of statin use before a diagnosis of pancreatic cancer with survival times of 648 participants in the Nurses' Health Study and Health Professionals Follow-up Study who were diagnosed with pancreatic adenocarcinoma from 2000 through 2013. We estimated hazard ratios (HRs) for overall mortality using Cox proportional hazards models with adjustment for potential confounders. We assessed the temporal association between prediagnosis statin use and cancer survival by 2-year lag periods to account for a possible latency period between statin use and cancer survival. Regular statin use before diagnosis of pancreatic cancer was associated with modestly prolonged survival compared with nonregular use (adjusted HR, 0.82; 95% CI, 0.69-0.97; P = .02). A 1-month longer median survival was observed in regular statin users compared with nonregular users. Regular statin use within the 2 years prior to cancer diagnosis was most strongly associ...Continue Reading

Citations

Nov 23, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·O Abdel-Rahman
Apr 9, 2020·Journal of Gastroenterology and Hepatology·Naminatsu TakaharaKazuhiko Koike
Jul 8, 2020·The Journal of Experimental Medicine·Tobiloba E OniDavid A Tuveson
Jan 3, 2020·Journal of Clinical Gastroenterology·Ryunosuke HakutaKazuhiko Koike
Jan 11, 2019·Cancer Discovery·Alessandro CarrerKathryn E Wellen
Aug 21, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Tsuyoshi HamadaBrian M Wolpin
Mar 10, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Natalia KhalafAaron P Thrift
Jun 3, 2021·Biochemical Pharmacology·Paul DentJohn F Hancock
Jul 6, 2021·World Journal of Clinical Cases·Chung-Tsui Huang, Yao-Jen Liang
Aug 17, 2021·Frontiers in Oncology·Hiromitsu HayashiHideo Baba

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