Prediagnostic prostate-specific antigen kinetics and the risk of biopsy progression in active surveillance patients

International Journal of Urology : Official Journal of the Japanese Urological Association
Viacheslav IremashviliSanoj Punnen

Abstract

To analyze the association between prediagnostic prostate-specific antigen kinetics and the risk of biopsy progression in prostate cancer patients on active surveillance, and to study the effect of prediagnostic prostate-specific antigen values on the predictive performance of prostate-specific antigen velocity and prostate-specific antigen doubling time. The study included 137 active surveillance patients with two or more prediagnostic prostate-specific antigen levels measured over a period of at least 3 months. Two sets of analyses were carried out. First, the association between prostate-specific antigen kinetics calculated using only the prediagnostic prostate-specific antigen values and the risk of biopsy progression was studied. Second, using the same cohort of patients, the predictive value of prostate-specific antigen kinetics calculated using only post-diagnostic prostate-specific antigens and compared with that of prostate-specific antigen kinetics based on both pre- and post-diagnostic prostate-specific antigen levels was analyzed. Of 137 patients included in the analysis, 37 (27%) had biopsy progression over a median follow-up period of 3.2 years. Prediagnostic prostate-specific antigen velocity of more than 2 ng/mL...Continue Reading

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Citations

Feb 4, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Koji Mitsuzuka
Jul 3, 2021·International Journal of Molecular Sciences·Belén Pastor-NavarroJosé Antonio López-Guerrero

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