Prediagnostic White Blood Cell DNA Methylation and Risk of Breast Cancer in the Prostate Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) Cohort.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Susan R SturgeonK. F. Arcaro

Abstract

White blood cell (WBC) DNA may contain methylation patterns that are associated with subsequent breast cancer risk. Using a high-throughput array and samples collected, on average, 1.3 years prior to diagnosis, a case-cohort analysis nested in the prospective Sister Study identified 250 individual CpG sites that were differentially methylated between breast cancer cases and noncases. We examined five of the top 40 CpG sites in a case-control study nested in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) Cohort. We investigated the associations between prediagnostic WBC DNA methylation in 297 breast cancer cases and 297 frequency-matched controls. Two WBC DNA specimens from each participant were used: a proximate sample collected 1 to 2.9 years and a distant sample collected 4.2-7.3 years prior to diagnosis in cases or the comparable timepoints in controls. WBC DNA methylation level was measured using targeted bisulfite amplification sequencing. We used logistic regression to obtain ORs and 95% confidence intervals (CI). A one-unit increase in percent methylation in ERCC1 in proximate WBC DNA was associated with increased breast cancer risk (adjusted OR = 1.29; 95% CI, 1.06-1.57). However, a one-unit i...Continue Reading

References

Feb 24, 2001·Controlled Clinical Trials·P C ProrokUNKNOWN Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial Project Team
Aug 3, 2002·Oncogene·Melanie Ehrlich
Nov 13, 2004·Cancer Biology & Therapy·Kesmic JacksonMelanie Ehrlich
Aug 17, 2006·Current Topics in Microbiology and Immunology·M CampanP W Laird
Jan 14, 2009·American Journal of Epidemiology·Debra L FoleyRichard Saffery
Mar 19, 2009·BMC Cancer·James V LaceyUNKNOWN Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial Project Team
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Apr 16, 2011·Bioinformatics·Felix Krueger, Simon R Andrews
Mar 6, 2012·Nature Methods·Ben Langmead, Steven L Salzberg
Apr 13, 2013·Journal of the National Cancer Institute·Zongli XuJack A Taylor
Apr 13, 2013·Journal of the National Cancer Institute·Montserrat García-ClosasRegina G Ziegler
Nov 20, 2014·Breast Cancer Research and Treatment·Gianluca SeveriLaura Baglietto
Jan 27, 2018·Environmental Health Perspectives·Dale P SandlerUNKNOWN Sister Study Research Team
Apr 17, 2019·Journal of the National Cancer Institute·Zongli XuJack A Taylor
May 19, 2019·Breast Cancer Research : BCR·Clara BodelonMontserrat Garcia-Closas

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