PMID: 376087Apr 1, 1979Paper

Predictability of immunologic phenotype of malignant lymphomas by conventional morphology: a study of 60 cases

Cancer
G FrizzeraJ H Kersey

Abstract

In order to test the immunologic validity of the Lukes-Collins (L-C) classification of the non-Hodgkin's lymphomas (ML), 60 ML in adult patients were studied and their B- or T-cell nature was predicted on a morphologic basis, without knowledge of the clinical history or the results of surface marker (SM) studies (SIg, C', Fc and E-rosettes), which were performed on cell suspensions and cryostat sections from the same specimens used for histology. There was a good correlation between morphologic types and SM (97% for the nodular ML, 81% for the diffuse). The predictions were not confirmed in 6 instances: one nodular ML typed as T; one convoluted lymphocytic ML typed as histiocytic; and four diffuse ML, predicted to be of B-type, bore no detectable SM ("Null" ML). It is concluded that the L-C morphologic criteria do allow in most cases the recognition of the B- or T-cell nature of ML, but cannot detect variations of the SM pattern which seem to affect the clinical behavior of these neoplasias. Thus, while the L-C classification seems immunologically sound, its clinical relevance still needs to be demonstrated.

References

Jan 1, 1977·Haematology and Blood Transfusion·R C BraylanC W Berard
Mar 2, 1978·The New England Journal of Medicine·R Warnke, R Levy
Apr 17, 1975·The New England Journal of Medicine·L Sen, L Borella
Jan 1, 1975·Journal of the National Cancer Institute·J H LeechR D Collins
Jul 1, 1972·The Journal of Experimental Medicine·H B Dickler, H G Kunkel
Dec 1, 1973·The Journal of Clinical Investigation·K J Gajl-PeczalskaR A Good
Jan 1, 1974·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·E Kaiserling, K Lennert
Apr 11, 1974·The New England Journal of Medicine·E S JaffeI Green
Oct 1, 1974·Cancer·R J Lukes, R D Collins

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Citations

Jan 2, 2014·Environmental Health Perspectives·Franco Scinicariello, Melanie C Buser
Jan 1, 1984·Journal of Toxicology and Environmental Health·D L BusbeeR D Wilson
Jan 1, 1989·Journal of Toxicology and Environmental Health·A L Kraus, I A Bernstein
May 1, 1984·Journal of the American Academy of Dermatology·T YamamuraS Sano
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A M HanbyW M Gregory
Apr 1, 1985·Hematological Oncology·R L WeissJ Marty
Oct 1, 1985·Cancer·I MirchandaniM S Pak
Nov 1, 1983·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·B ChristenssonP Biberfeld

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