Predictable reduction in anticoagulant activity of warfarin by small amounts of vitamin K.

Acta Medica Scandinavica
P Andersen, H C Godal

Abstract

After withdrawal of warfarin (Marevan), 48-72 hours are required to raise the Thombotest values from a therapeutic level (range 5-10%) to 12% or higher. By i.v. administration of 1 mg vitamin K1 (Konakion) and without changing the dose of the anticoagulant, this effect could be obtained within 24 hours. Furthermore, the effect of vitamin K vanished within 2-5 days. The use of small amounts of vitamin K may therefore be a simple and reliable way of obtaining a rapid, temporary reduction in anticoagulant effect.

References

Nov 1, 1967·Acta Medica Scandinavica·E A LoeligerH C Hemker
Nov 1, 1967·Thorax·J Wieberdink

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Citations

Mar 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·J E Martin, D M Lutomski
Mar 7, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·C G FondevilaM D Pinto
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Dec 17, 2008·Hematology·Francesco Dentali, Mark A Crowther
Sep 12, 2006·Journal of Thrombosis and Haemostasis : JTH·F DentaliM Crowther
Sep 1, 2001·British Journal of Haematology·M Makris, H G Watson
Nov 28, 2001·Hematology·J A GinsbergT L Ortel

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