Predicted Indirectly ReCognizable HLA Epitopes Class I Promote Antileukemia Responses after Cord Blood Transplantation: Indications for a Potential Novel Donor Selection Tool

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Kirsten A ThusEric Spierings

Abstract

Unrelated cord blood transplantation (UCBT) provides a curative therapy for patients with hematological malignancies. The effect of HLA mismatches in UCBT is currently the subject of debate. HLA-mismatched UCBT may lead to improved leukemia control but also to graft-versus-host disease (GVHD), resulting in nonrelapse mortality (NRM). The aim of this study was to investigate whether indirect recognition of mismatched HLA provides an explanation for the graft-versus-tumor effect and risk of GVHD. The probability of indirect recognition was predicted by the Predicted Indirectly ReCognizable HLA Epitopes (PIRCHE) model. The effect of the numbers of PIRCHE presented on HLA class I and II (PIRCHE-I and -II) was studied in 134 pediatric patients. To study the effects of higher numbers of PIRCHE, patients were divided in 2 equally sized groups, using the median number of PIRCHE as cutoff values. Proportional hazard models and competing risk analyses were performed to study the effect of PIRCHE on the clinical outcomes relapse, acute and chronic GVHD, NRM, and disease-free and overall survival. Above median PIRCHE-I were associated with reduced relapse risk (HR, .26; 95% CI, .07 to .94; P = .04), evaluating the 50 patients transplanted ...Continue Reading

References

Jan 26, 2013·Haematologica·Yoshiko AtsutaUNKNOWN HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation
Oct 22, 2013·Blood·Mary EapenUNKNOWN Center for International Blood and Marrow Transplant Research, Netcord, Eurocord, and the European Group for Blood and Marro
May 27, 2014·Frontiers in Immunology·Kirsten A ThusEric Spierings
Jul 2, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kirsten A ThusEric Spierings
Jul 24, 2014·The New England Journal of Medicine·Loren GragertMartin Maiers
Oct 30, 2014·The New England Journal of Medicine·John E WagnerUNKNOWN Blood and Marrow Transplant Clinical Trials Network

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Citations

Jul 2, 2016·Blood·Jaap Jan Boelens
Dec 19, 2019·Pediatric Blood & Cancer·Wiebke StengerLena Oevermann
Feb 22, 2018·International Journal of Immunogenetics·K Geneugelijk, E Spierings
Jul 26, 2018·Blood Advances·Esteban Arrieta-BolañosStephen R Spellman
Apr 21, 2021·British Journal of Haematology·Sergio QuerolAlejandro Madrigal

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