Predicted sequence of cortical tau and amyloid-β deposition in Alzheimer disease spectrum

Neurobiology of Aging
Hanna ChoChul Hyoung Lyoo

Abstract

We investigated sequential order between tau and amyloid-β (Aβ) deposition in Alzheimer disease spectrum using a conditional probability method. Two hundred twenty participants underwent 18F-flortaucipir and 18F-florbetaben positron emission tomography scans and neuropsychological tests. The presence of tau and Aβ in each region and impairment in each cognitive domain were determined by Z-score cutoffs. By comparing pairs of conditional probabilities, the sequential order of tau and Aβ deposition were determined. Probability for the presence of tau in the entorhinal cortex was higher than that of Aβ in all cortical regions, and in the medial temporal cortices, probability for the presence of tau was higher than that of Aβ. Conversely, in the remaining neocortex above the inferior temporal cortex, probability for the presence of Aβ was always higher than that of tau. Tau pathology in the entorhinal cortex may appear earlier than neocortical Aβ and may spread in the absence of Aβ within the neighboring medial temporal regions. However, Aβ may be required for massive tau deposition in the distant cortical areas.

Citations

Oct 28, 2019·Current Alzheimer Research·Anuruddhika Udayangani RathnayakeHee-Guk Byun
May 1, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Min Seok BaekChul Hyoung Lyoo
May 28, 2020·Nature Communications·Jacob W VogelUNKNOWN Swedish BioFinder Study
Jan 13, 2019·Molecular Psychiatry·Antoine LeuzyAgneta Nordberg
Apr 24, 2021·Journal of the American Geriatrics Society·Sharon LamUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 1, 2021·Nature Medicine·Jacob W VogelOskar Hansson
Mar 31, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Hanna ChoChul Hyoung Lyoo
Jul 6, 2021·Journal of Alzheimer's Disease : JAD·Giulia QuattriniUNKNOWN PharmaCog Consortium
Oct 17, 2021·Alzheimer's Research & Therapy·Tengfei GuoUNKNOWN Alzheimer’s Disease Neuroimaging Initiative

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