Predicting 3-year survival in older people with intellectual disabilities using a Frailty Index

Journal of the American Geriatrics Society
Josje D SchoufourMichael A Echteld

Abstract

To analyze the relationship between frailty and survival in older people with intellectual disabilities (IDs). Population-based longitudinal observational study. Three Dutch care provider services. Individuals with borderline to profound ID aged 50 and older (N=982). A frailty index (FI) including 51 health-related deficits was used to measure frailty. Mean follow-up was 3.3 years. The Cox proportional hazards model was used to evaluate the independent effect of frailty on survival. The discriminative ability of the FI was measured using a receiver operating characteristic (ROC) curve. Greater FI values were associated with greater risk of death, independent of sex, age, level of ID, and Down syndrome. There was a nonlinear increase in risk with increasing FI value. For example, mortality risk was 2.17 times as great (95% confidence interval (CI)=0.95-4.95) for vulnerable individuals (FI 0.20-0.29) and 19.5 (95% CI=9.13-41.8) times as great for moderately frail individuals (FI 0.40-0.49) as for relatively fit individuals (FI<0.20). The area under the ROC curve for 3-year survival was 0.78. Although the predictive validity of the FI should be further determined, it was strongly associated with 3-year mortality. Care providers wo...Continue Reading

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Citations

Feb 14, 2016·Research in Developmental Disabilities·C F de WinterH M Evenhuis
Nov 14, 2015·Age and Ageing·Josje D SchoufourHeleen M Evenhuis
Apr 1, 2015·Tijdschrift voor gerontologie en geriatrie·Josje D SchoufourHeleen M Evenhuis
Aug 9, 2016·Research in Developmental Disabilities·Cis VrijmoethMarieke Groot
Dec 28, 2017·American Journal on Intellectual and Developmental Disabilities·Josje D SchoufourDederieke A Festen
Apr 6, 2019·Journal of Applied Research in Intellectual Disabilities : JARID·Alyt Oppewal, Thessa I M Hilgenkamp
Mar 14, 2020·Journal of Applied Research in Intellectual Disabilities : JARID·Alyt Oppewal, Thessa I M Hilgenkamp
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Nov 17, 2016·Tijdschrift voor gerontologie en geriatrie·Alyt OppewalThessa I M Hilgenkamp
Jul 27, 2017·European Journal of Nutrition·Sandra C M de HaasJosje D Schoufour
Apr 20, 2019·Mechanisms of Ageing and Development·Kenneth Rockwood, Susan E Howlett
Apr 7, 2021·Journal of Policy and Practice in Intellectual Disabilities·Dederieke A M FestenAlyt Oppewal
Dec 24, 2021·Journal of Intellectual Disability Research : JIDR·J D SchoufourD A M Maes-Festen

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