Predicting 5- and 10-Year Mortality Risk in Older Adults With Diabetes.

Diabetes Care
Kevin N GriffithPaul R Conlin

Abstract

Several diabetes clinical practice guidelines suggest that treatment goals may be modified in older adults on the basis of comorbidities, complications, and life expectancy. The long-term benefits of treatment intensification may not outweigh short-term risks for patients with limited life expectancy. Because of the uncertainty of determining life expectancy for individual patients, we sought to develop and validate prognostic indices for mortality in older adults with diabetes. We used a prevalence sample of veterans with diabetes who were aged ≥65 years on 1 January 2006 (N = 275,190). Administrative data were queried for potential predictors that included patient demographics, comorbidities, procedure codes, laboratory values and anthropomorphic measurements, medication history, and previous health service utilization. Logistic least absolute shrinkage and selection operator regressions were used to identify variables independently associated with mortality. The resulting odds ratios were then weighted to create prognostic indices of mortality over 5 and 10 years. Thirty-seven predictors of mortality were identified: 4 demographic variables, prescriptions for insulin or sulfonylureas or blood pressure medications, 6 biomarke...Continue Reading

References

Nov 27, 2002·Circulation·Peter Libby, Jorge Plutzky
Feb 16, 2006·JAMA : the Journal of the American Medical Association·Sei J LeeKenneth E Covinsky
Mar 1, 2006·Diabetes Care·John D Piette, Eve A Kerr
Feb 17, 2007·Medical Care·Denise M HynesLinda Kok
Nov 23, 2007·Journal of the American Geriatrics Society·Elise C CareyLouise C Walter
Sep 24, 2008·Diabetes Care·Brian J WellsMichael W Kattan
Dec 26, 2008·European Heart Journal·Jose LealPhilip M Clarke
Mar 26, 2009·The New England Journal of Medicine·Simon FinferJuan J Ronco
Sep 29, 2009·European Journal of Internal Medicine·Michael G ClarkeA L Widdison
Dec 1, 2009·Annals of Epidemiology·Reginald D Tucker-SeeleyGlorian Sorensen
Jan 7, 2011·Journal of Clinical Epidemiology·Joshua J GagneSebastian Schneeweiss
Mar 5, 2011·PloS One·Stefano FinazziGuido Bertolini
Jan 12, 2012·JAMA : the Journal of the American Medical Association·Lindsey C YourmanAlexander K Smith
Jan 21, 2012·Journal of the American Geriatrics Society·LeChauncy D WoodardLaura A Petersen
Jun 1, 2013·Cardiovascular Diabetology·Katherine EspositoUNKNOWN Associazione Medici Diabetologi
Aug 2, 2013·Diabetes Care·Vojtech Hainer, Irena Aldhoon-Hainerová
Mar 20, 2015·Circulation. Cardiovascular Interventions·John A Bittl
Feb 28, 2016·BMC Medical Research Methodology·Liping TongTina Esposito
Sep 15, 2016·Journal of the American Heart Association·Ki-Chul SungChristopher D Byrne
Dec 10, 2017·Diabetes Care·UNKNOWN American Diabetes Association
Oct 12, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ariela R OrkabyJane A Driver
Jan 16, 2019·JAMA Network Open·Sherri Rose
Jun 6, 2019·The New England Journal of Medicine·Peter D ReavenUNKNOWN VADT Investigators

❮ Previous
Next ❯

Citations

Dec 11, 2020·Diabetes Care·UNKNOWN American Diabetes Association
Mar 12, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·David ChengAriela R Orkaby
Apr 8, 2021·Expert Opinion on Pharmacotherapy·André J Scheen

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.